Magnesium Sulfate Combined With Intraarticular Cocktail Injection for Analgesia After Simultaneous Bilateral Total Knee Arthroplasty
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 80
- 主要终点
- VAS score
研究概览
简要总结
Total knee arthroplasty is a safe procedure with excellent outcome. In recent years, simultaneous bilateral total knee arthroplasty has become more popular. In views of enhanced recovery after surgery, intraarticular cocktail injection for pain control has been developed. However, the safety accumulation dose for simultaneous bilateral knee injection is still an issue. Recently, adding magnesium sulfate to intraarticular cocktail injection in unilateral total knee arthroplasty has been proved effective for prolong pain control. We tempt to conduct a double blinded study to evaluate that whether adding magnesium sulfate intraarticular cocktail injection to one of the knees in simultaneous bilateral total knee arthroplasty patient could effectively decrease pain score with less analgesia dose or not.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •bilateral knee advanced osteoarthritis or osteonecrosis who tend to receive simultaneous bilateral total knee arthroplasty
排除标准
- •hypersensitivity to magnesium sulfate
- •hypermagnesemia
- •severe cardiac, hepatic or renal compromised
研究组 & 干预措施
Cocktail injection with Magnesium Sulfate
Cocktail injection with Marcaine, Dexamethasone, normal saline and Magnesium Sulfate
干预措施: Magnesium sulfate (Drug)
结局指标
主要结局
VAS score
时间窗: day 0, day 1, day 2, day 3, day 7
muscle power
时间窗: day 0, day 1, day 2, day 3
Straight leg raised test
时间窗: day 0, day 1, day 2, day 3
active range of motion
时间窗: day 0, day 1, day 2, day 3
次要结局
- Magnesium level in blood(day 0, day 1)
- Calcium level in blood(day 0, day 1)