Renal Functional Imaging for Non-invasive Evaluation and Diagnostics - ReFINED

niversitair Medisch Centrum Utrecht0 个研究点目标入组 35 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•- Subject is >= 18 years of age
•- Subject agrees to have all study procedures performed, and is competent and willing to provide written, informed consent to participate in this clinical study;Exclusively for subjects in the CKD group:
•- Subject has a GFR of 30-60 ml/min/1.73 m2 ;Exclusively for subjects in the hypertension group:
•- Subject has a systolic blood pressure of >=140 mmHg and/or a diastolic blood pressure of >=90 mmHg based on average of 3 office blood pressure readings, or a 24-h ambulatory blood pressure of >=140 mmHg systolic and/or >=90 mmHg diastolic; or is on antihypertensive medication
•- Subject has no treatable secondary cause of hypertension
•- Subject has no medical record of impaired kidney function (as defined by a GFR <60 ml/min/1.73m2);Exclusively for healthy volunteers:
•- Subject has no medical record of impaired kidney function (as defined by a GFR <60 ml/min/1.73m2)
•- Subject has no medical record of hypertension (as defined by a systolic blood pressure of >=140 mmHg and/or a diastolic blood pressure of >=90; or the use of antihypertensive medication)
•- Subject can be age matched within a range of ±5 years to one or more subjects in the CKD and hypertension groups

•- Subject has an allergy or intolerance to any of the agents used in the study
•- Subject has any contraindications for MRI according to screening protocol radiology department UMCU
•- Subject is pregnant, nursing or planning to be pregnant
•- Subject has a known, unresolved history of drug use or alcohol dependency, lacks the ability to comprehend or follow instructions, or would be unlikely or unable to comply with study follow-up requirements
•- Subject refuses to be informed of chance findings possibly relevant to their health
•- Subject is currently being treated with drugs that cause salt retention (e.g., systemic corticosteroids and fludrocortisone);Exclusively for healthy volunteers and hypertensive subjects:
•- Subject has no known renal disease

发起方

niversitair Medisch Centrum Utrecht