Trends of Immunosuppression Therapy and Their Effectiveness in Patients With Liver Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 314
- 试验地点
- 1
- 主要终点
- incidence of graft and patient mortality, treatment-related complications
研究概览
简要总结
Conventionally, the outcome of liver transplantation is usually reported in terms of graft and patient survival, medical and surgical complications, but lack of health-related quality of life (HRQOL) that might be associated with immunosuppression complications (e.g., diabetes, hypertension, dyslipidemia, obesity, metabolic syndrome, cardiovascular disease, renal dysfunction, osteoporosis, and de novo malignancy), disease recurrence, and rejections after transplantation.
详细描述
Specific aims are proposed to achieve in this study:
- To compare graft and patient survival rate, incidence of treatment-related adverse effects between different patterns of immunosuppression combination among patients received post-liver transplant care in Kaohsiung Chang Gung Memorial Hospital (KCGMH), Taiwan.
- To quantify the long-term health impacts of immunosuppressive regimens on quality-adjusted life expectancy (QALE), the loss-of-QALE relating to immunosuppression therapy, and types of transplantation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age at liver transplantation is at least 20 years
- •Inclusion Criteria:
- •age at liver transplantation is at least 20 years
排除标准
- •deceased patient
- •cannot obtain inform consent
- •age <20 years
结局指标
主要结局
incidence of graft and patient mortality, treatment-related complications
时间窗: 5 years
Patient will be followed from the date of liver transplantation to the occurence of outcome event for 5 years
次要结局
- health-related quality of life(5 years)
研究者
Chien-Ning Hsu
Clinical Pharmacist
Chang Gung Memorial Hospital