Comparative Responses to 15 Different Antidepressants in Major Depressive Disorder - Results From a Long-term Nation-wide Population-based Study Emulating a Randomized Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 73,336
- 试验地点
- 1
- 主要终点
- Response
研究概览
简要总结
Achieving results from RCTs with high internal and external validity is a major challenge within psychiatry due to the nature of psychiatric illnesses. The Investigators will conduct a "real world" naturalistic nation-wide population-based longitudinal register linkage study comparing long-term responses to all kinds of antidepressants in patients with major depressive disorder emulating a randomized trial.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients with a psychiatric contact (as inpatients or outpatients) in the period from 1995 to 2018 with a first main index diagnosis of a single depressive episode or recurrent depressive disorder (ICD-10 code: F32-F33.9) with an outpatient purchase of an antidepressant after the depression diagnosis (N=73.336).
排除标准
- 未提供
研究组 & 干预措施
TCA
Group 6: Tricyclic antidepressants (reference: amitriptyline)
Comparisons of Nortriptyline, Imipramine, Clomipramine and Dosulepin with amitriptyline
干预措施: Antidepressant (Drug)
SSRI
Group 1: Selective serotonin reuptake inhibitors (reference: sertraline)
Comparisons of the following with sertraline:
Citalopram, Fluoxetine, Paroxetine, Escitalopram
干预措施: Antidepressant (Drug)
NARI
Group 2: Noradrenaline reuptake inhibitors (reference: sertraline) Comparisons of the following with sertraline: Reboxetine
干预措施: Antidepressant (Drug)
SNRI
Group 3: Serotonin and noradrenaline reuptake inhibitors (reference: venlafaxine) Comparisons of Duloxetine with venlafaxine
干预措施: Antidepressant (Drug)
ARI
Group 4: Adrenergic receptor inhibitors (reference: Mirtazapine) Comparisons of Mianserin with Mirtazapine
干预措施: Antidepressant (Drug)
Other drugs
Group 5: Other drugs (reference: sertraline) Comparisons of Vortioxetine and Agomelatine with sertraline
干预措施: Antidepressant (Drug)
结局指标
主要结局
Response
时间窗: 2 years
Response was defined as continuous monotherapy with an antidepressant drug without switch to or add-on of another antidepressant drug, an antipsychotic drug or lithium or hospitalization with a main ICD-10 diagnosis of a single depressive episode or recurrent depressive disorder .
次要结局
未报告次要终点