Urinary Biomarkers for Prediction of Pregnancy-related Acute Kidney Injury in Parturient with Pre-Eclampsia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- 1 diagnostic performance of and best cutoff values of the urinary markers product of TIMP2 and IGFBP to differentiate between AKI and nonAKI IN preeclampsia
研究概览
简要总结
To predict acute kidney injury in pre-eclampsia patients by using biomarkers TIMP2 and IGFBP7.The observational study will be conducted in PGIMER to study the diagnostic performance of and best cut-off values of the urinary markers (product of TIMP-2 and IGFBP7) to differentiate between AKI and non-AKI in preeclampsia patients. The urine sample collection for the biomarkers will be attempted within 2 hours from admission to the labour room and repeated after 24hrs and 48 hrs. The potential presence of these biomolecules will be analyzed using an enzyme-linked immunosorbent assay.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 16.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- Female
入选标准
- •All pregnant patients who are diagnosed with eclampsia, pre-eclampsia and severe eclampsia.
排除标准
- •Pre-existing renal insufficiency(diabetes mellitus associated with renal disease) Gestational diabetes and peripheral vascular disease Use of nephrotoxic drugs Pre-existing hypertension with renal disease Refusal to participate Inability to give informed consent.
结局指标
主要结局
1 diagnostic performance of and best cutoff values of the urinary markers product of TIMP2 and IGFBP to differentiate between AKI and nonAKI IN preeclampsia
时间窗: At the time of admission and follow up till 48 hrs
次要结局
- 1.To compare the demographic and clinical profiles of pregnant females in AKI and non-AKI groups.(2.Serum urea & Creatinine)
研究者
Apoorva Sharma
Post Graduate Institute Of Medical Education And Research