Effect of Intraoperative Oxygen Tension on Patient Outcomes After Cardiac Surgery With Cardiopulmonary Bypass: a Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- hospital LOS
研究概览
简要总结
Conventionally, a relatively high level of fraction of inspired oxygen (FiO2) has been used for secure a margin of safety in patients undergoing cardiac surgery using cardiopulmonary bypass (CPB). Since the potential adverse effects of hyperoxemia (via reactive oxygen species, vasocontriction, perfusion heterogeneity, myocardiac injury, etc.), various studies on this topic has been performed. However, the results are conflicting and inconsistent, and the consensus about whether the use of additional oxygen supply in cardiac surgery using CPB has not been reached among practitioners yet.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients scheduled for cardiac surgery using cardiopulmonary bypass
排除标准
- •Planned implementation of deep hypothermic circulatory arrest
- •Preoperative respiratory support with the fraction of inspired oxygen of 0.5 and more.
研究组 & 干预措施
FiO2 1.0
干预措施: Fraction of inspired oxygen level (Other)
FiO2 0.5
干预措施: Fraction of inspired oxygen level (Other)
结局指标
主要结局
hospital LOS
时间窗: From the beginning of surgery until the hospital discharge after surgery through study completion, an expected average of two weeks
length of hospital stay after cardiac surgery using cardiopulmonary bypass
次要结局
未报告次要终点
研究者
Yunseok Jeon
Professor of Anesthesiology and Pain Medicine
Seoul National University Hospital