NCT01715337已完成不适用
Effects of Pulmonary Rehabilitation on Muscle Fibre Composition and Capillaries in Patients With Chronic Obstructive Pulmonary Disease (COPD)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Change in the amount of capillaries in muscle fibre type I
研究概览
简要总结
Pulmonary rehabilitation has been established as an evidence-based and recommended therapy in patients with chronic obstructive pulmonary disease (COPD). The aim of our study is to show a potential change in muscle fibre composition and in the amount of capillaries in quadriceps muscle from pre tob post 3-week rehabilitation. Pulmonary rehabilitation includes standardised exercise training, e.g. cycling and strength training for major muscle groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •chronic obstructive pulmonary disease
- •FEV1%pred. < 50%
排除标准
- •acute exacerbation
- •exacerbation in the last 4 weeks
结局指标
主要结局
Change in the amount of capillaries in muscle fibre type I
时间窗: change from pre (day 1) to post rehabilitation (day 21)
次要结局
- Change in the cross-sectional area of muscle fibre type IIa(Change from pre (day 1) to post rehabilitation (day 21))
- Change in the amount of capillaries in muscle fibre type IIa(Change from pre (day 1) to post rehabilitation (day 21))
- Change in the cross-sectional area of muscle fibre type I(Change from pre (day 1) to post rehabilitation (day 21))
研究者
Klaus Kenn
Head physician (department of pneumology)
Schön Klinik Berchtesgadener Land
研究点 (2)
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