Pattern and Short Term Outcomes of Renal Affection in Patients With Liver Cirrhosis in Al-Rajhi Liver Hospital
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 290
- 试验地点
- 1
- 主要终点
- In-hospital mortality
研究概览
简要总结
- To characterize the pattern and the prevalence of renal affection among liver cirrhosis patients.
- To evaluate the short-term outcomes of those patients.
详细描述
Liver cirrhosis is a chronic liver disease characterized by significant scarring and dysfunction. One of its common complications is renal affection , which can significantly impact patient outcomes .
Aetiology of AKI can be categorized into three main types. These are prerenal (results from decreased renal perfusion), intrinsic renal (acute tubular necrosis), and postrenal AKI. In patients on admission, acute tubular necrosis is a common type of intrinsic AKI .
The development of portal hypertension in patients with liver cirrhosis leading to a reduction in systemic vascular resistance as a result of primary arterial vasodilation in the splanchnic circulation is the primary cause of AKI in cirrhotics. This mechanism primarily leads to hepatorenal syndrome. In addition, the underlying causes of liver cirrhosis can be the cause of intrinsic renal disease .
Early identification and management of AKI may improve outcomes. AKI in patients with liver cirrhosis in Egypt and their impact on inpatient mortality are largely unknown. This study was aimed at determining the prevalence, precipitating factors, predictors, and in-hospital mortality of AKI in patients with liver cirrhosis admitted at Al-Rajhi liver hospital at Egypt .
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with liver cirrhosis admitted to the department .
排除标准
- •Patients with known preexisting chronic kidney disease according to KDIGO and EASL 2018 definitions ( defined as functional GFR <60 ml/min per 1.73 m 2 for ≥3 months or structural kidney damage for ≥3 months ).
- •Patient refusal to give informed consent ( or his first degree relatives in case of disturbed conscious level).
结局指标
主要结局
In-hospital mortality
时间窗: Through the study completion , average 6 months
Mortality during hospital stay
Phenotypes of acute kidney injury across geographic areas
时间窗: Baseline ( at admission ), then through the study completion, average 6 months
Characteristics of acute kidney injury (clinical type and stage)
次要结局
- 28-day mortality(28 days)
- Resolution of AKI(Hospital stay (up to 90 days))
- Development of CKD(90 days)
研究者
Ahmed Radwan Riad
Lecturer
Assiut University