NCT07208123尚未招募不适用
A Bidirectional Cohort Study of Single-Cell Sequencing and Single-Cell Spatial Transcriptomics in Chronic COPD
Tongji University1 个研究点 分布在 1 个国家目标入组 150 人开始时间: 2025年9月30日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Transcriptomic profile analysis of lung tissues
研究概览
简要总结
This study is an ambispective cohort study, the sample from patients were from both previously stored and freshly collected . The objective of this study is to investigate the molecular pathological changes underlying the development of chronic obstructive pulmonary disease (COPD). We will use single cell sequencing technology to analyze lung tissue samples from patients who underwent lung resection, with lung tissue from patients without COPD serving as controls. This research aims to provide insights into the pathogenesis of COPD.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Receiving lung resection surgery at the hospital for any reason；
- •Diagnosed with COPD according to the 2024 GOLD guidelines；
- •Tissue samples that meet collection requirements and are either agreed to be collected or already preserved；
排除标准
- •Improper preservation of pathological specimens, refusal to consent to sample collection, or incomplete clinical information；
- •Combined with other factors causing obstructive airflow limitation;
- •Diagnosed with asthma according to the GINA 2023 guidelines and with a history of asthma exacerbations within the past year;
- •Combined with Advanced lung cancer;
- •Receiving systemic immunosuppressive medications such as anti-rejection drugs;
结局指标
主要结局
Transcriptomic profile analysis of lung tissues
时间窗: until end of surgery
次要结局
未报告次要终点
研究者
Fang Chen
professor
Tongji University
研究点 (1)
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