NCT04448951招募中不适用
Immune Homeostasis in Patients With Sepsis and Septic Shock: a Single Center Observational Study
Charles University, Czech Republic1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2020年9月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Immune response description - flow cytometry
研究概览
简要总结
Detailed description of immune response and its dynamics in sepsis and septic shock patiens by means of transcriptomics, flow-cytometry and cytokine analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •sepsis/septic shock (SEPSIS-3)
- •informed consent
- •inclusion within first 24hrs after development/diagnosis of septic shock
排除标准
- •disagreement of the patient or legal representative with the entry into the study
- •patients with primary or secondary immunodeficiency
- •presence of active haematological malignancy or an active non-haematological malignancy
结局指标
主要结局
Immune response description - flow cytometry
时间窗: 2024 - 2026
Detailed description of immune response analyzed by mean of flow cytometry
Immune response description - ELISA
时间窗: 2024 - 2026
Detailed description of immune response analyzed by mean of ELISA
Immune response description - transcriptomics
时间窗: 2024 - 2026
Detailed description of immune response analyzed by mean of transcriptomic analysis
次要结局
- Diagnostic "immune status" panel(2026 - 2028)
研究者
Thomas Karvunidis
Principal investigator
Charles University, Czech Republic
研究点 (1)
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