Vitamin D Deficiency in the Elder Patients of General Departments and Its Treatment During the Hospitalization
试验速览
- 阶段
- 3 期
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- vitamin D status
研究概览
简要总结
The purpose of the study is to examine the vitamin D state of elder patients in therapeutic departments and to compere the treatment during the hospitalization with the out-patient treatment.
详细描述
Today vitamin D is thought to be one of the most important vitamins in the human body. It's made in the skin during the sun expose, so it must be sufficient in so sunny countries as Israel. Although many old people in our country suffer from vitamin d deficiency which bring them to recurrent falls, osteoporotic fractures and physical disability. This problem is still underestimated by health authorities in different countries.
In this study we will examine the vitamin D state of the therapeutic patient older than 65 year including their physical self-estimation, muscle strength measurement and gait-and-balance tests. Then, according to the resent studies, we will treat the patients in the interventional group with two large doses of vitamin D during a month. After that we will compere their health and physical state with the patients treated in the out-hospital department.
So we will try to find a useful approach to treat the vitamin D deficiency during the hospitalization.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •the patient was admitted to a general department of Rambam Medical Center for any reason from March to May 2008
- •the patient is 65 years old or older
- •the patient is in a good health, based on medical history, physical examination and laboratory screening evaluation.
排除标准
- •renal failure with creatinine level more then 1.3 mg/dL or nephritic syndrome.
- •liver disease with transaminase rise three times from normal level.
- •nephrolithiasis in the last fife years.
- •primary hyperparathyroidism, hypoparathyroidism or pseudohypoparathyroidism.
- •advanced cancer.
- •chronic diarrhea or malabsorption.
- •granulomatous disease (sarcoidosis, tuberculosis, lymphoma).
- •patients, who are receiving barbiturates, rifampin, anticonvulsants.
- •patients, who are receiving digitalis.
- •patients, who are receiving glucocorticoids for more than two weeks during the study.
- •advanced dementia.
研究组 & 干预措施
2
Arm 2 - the patients vitamin D status will be checked during the hospitalization and they will receive the recommendation to treat the vitamin D deficiency in the out-patient department.
1
Arm 1 - the patients will receive two large doses of vitamin D.
干预措施: Alpha-D3 (Dietary Supplement)
结局指标
主要结局
vitamin D status
时间窗: two month
次要结局
- physical performance, health conditions, arm strength, gait and balance state.(two month)