Targeted Assessment of Cognition and Tactical-performance With Ingested Ketones
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Cognitive Performance
研究概览
简要总结
The goal of this study is to determine whether consuming a commercially available exogenous ketone supplement (KetoneIQ®) affects cognition, specifically marksmanship, under physical stress (i.e., exhaustive exercise).
The main questions we seek to answer are:
- Does the supplement save cognitive performance under stress compared to a placebo?
- Does the supplement improve marksmanship under stress compared to a placebo?
详细描述
In this study, 20 active SWAT team members will be randomized into two groups: Exogenous Ketone Supplement (EKS) and Placebo (PLA).
Participants will complete the trial in a crossover manner (meaning each participant will complete both EKS and PLA conditions)
Our primary outcome of interest is changes in cognitive performance following an exhaustive exercise bout. Secondary outcomes include: changes in marksmanship accuracy and speed, and changes in select biomarkers (catecholamines, cortisol, and BDNF).
Although ketone supplements are marketed for energy and cognitive performance, little is known about how they affect biological markers during stressful environments. Findings from this study may help inform safe, evidence-based use of such supplements among tactical athletes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Active Member of an accredited Law Enforcement Special Weapons and Tactics Team (SWAT)
- •Health and capable of meeting testing requirements
排除标准
- •Following a low-carbohydrate ketogenic diet
- •Self-reported Pregnancy
- •Allergy to testing materials
- •Currently using exogenous ketone supplements within one week of testing
研究组 & 干预措施
KetoneIQ®
Supplement of study. KetoneIQ® dosed at 0.6g/kg body weight
干预措施: KetoneIQ® (Dietary Supplement)
Placebo
Flavor, texture, color matched. Very low calorie.
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
Cognitive Performance
时间窗: Baseline (minute 0) to Post Suppelementation (minute 45) to Post Exercise (minute 60)
Changes in Score for the Trail Making Test, Psychomotor Vigilance Test, and Flanker Test.
次要结局
- Changes in Circulating Concentration of Brain Derieved Neurotrophic Factor(Baseline (minute 0) to post supplementation (minute 45) to post exercise (minute 60))
- Changes in Circulating Catecholamines Concetrations(From baseline (minute 0) to post supplemenation (minute 45) to post exercise (minute 60))
- Changes in Circulating Cortisol Concentration(From baseline (minute 0) to post supplemetation (minute 45) to post exercise (minute 60))
- Weapons Familarization Score(Post Exercise (minute 60))
- Marksmanship efficiency(Post Exercise (minute 60))
研究者
Michael J. Ormsbee
Professor
Florida State University