Advancing PET-CT Imaging With Photon Counting Detector CT
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- improve PET image w/ non-contrast PCD-CT data
研究概览
简要总结
This pilot study evaluates the clinical utility of photon counting detector computed tomography (PCD-CT) in PET-CT imaging for head and neck cancer. Twenty adult patients undergoing standard-of-care PET-CT will also receive PCD-CT imaging. The study compares image quality and diagnostic confidence between conventional energy-integrating detector CT (EID-CT) and PCD-CT for attenuation correction and anatomical imaging.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Scheduled for or completed standard-of-care PET-CT of head and neck within ≤30 days
排除标准
- •Non-diagnostic PET-CT
- •Intervening therapy between scans
- •Iodinated contrast allergy
- •Renal insufficiency (GFR < 45)
- •Pregnancy
- •Gross motion artifacts
研究组 & 干预措施
PCD-CT
To compare the subjective image quality of PET images constructed using non-contrast PCD-CT image data to PET images constructed using conventional standard-of-care non-contrast EID-CT image data by performing a qualitative analysis of diagnostic confidence as determined by board-certified radiologists/nuclear medicine physicians during image review.
干预措施: PET CT (Other)
PET CT scan
To compare the image quality of PET images constructed using non-contrast PCD-CT image data to PET images constructed using conventional standard-of-care non-contrast EID-CT image data by performing a quantitative analysis of measurable image quality parameters.
干预措施: PCD-CT (Other)
结局指标
主要结局
improve PET image w/ non-contrast PCD-CT data
时间窗: 2 years
We expect that the subjective PET image quality will be improved by using non-contrast PCD-CT data for construction resulting in higher diagnostic confidence; demonstrating a case for the integration of PCD-CT into standard of care clinical PET-CT imaging in the future. There will be no direct benefit to study participants and the outcome will not be directly reported to the treatment team or patient and will not impact treatment or care received.
次要结局
未报告次要终点
研究者
Kevin Horn
Research Instructor-Faculty
Medical University of South Carolina