Study of the Correlation Between Muscle Oxygenation and Motor Function in Children With Neuromuscular Disease.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Muscular oxygenation
研究概览
简要总结
Preliminary data underline the fact that muscular deoxygenation during training happens earlier in adult patients suffering from neuromuscular disorders in comparison to controls. Up to date, pediatric data are lacking.
The study aims at demonstrating if a correlation exists between the motor deficiency and the muscular deoxygenation in children suffering from neuromuscular disorders.
详细描述
Preliminary data underline the fact that muscular deoxygenation during training happens earlier in adult patients suffering from neuromuscular disorders in comparison to controls, as it was demonstrated in Becker muscular dystrophy patients and fascioscapulo humeral muscular dystrophy. Moreover, the deoxygenation kinetics was positively correlated to the functional status and the muscular deficiency severity. However, no pediatric study has been conducted on this topic up to date.
The aim of the study is to determine if a correlation exists in children suffering from neuromuscular diseases:
- between muscular oxygenation and the percentage of the 6 minutes walking test performed in the routine medical care
- between muscular oxygenation and the total and D1 motor function measure value
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children from 6 to 18 years-old suffering from a neuromuscular disorder
- •Able to walk, with or without help
排除标准
- •Hypoxia secondary to heart or lung disease
- •Visual impairment (<5/10)
- •Parents refusal concerning data storage
结局指标
主要结局
Muscular oxygenation
时间窗: 6 minutes
Muscular oximetry
次要结局
- Motor function(25 minutes)
- 6 minutes walking distance(6 minutes)