NCT01634984Unknown不适用
The Diagnostic Technology Applied Research of CDK5RAP2 in Breast Cancer
Tianjin Medical University Cancer Institute and Hospital1 个研究点 分布在 1 个国家目标入组 500 人开始时间: 2012年1月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 500
- 试验地点
- 1
研究概览
简要总结
Selected 400 cases of women with primary breast cancer who were treated with operation randomly, then detect the expression of CDK5RAP2 of cancer tissue. At the same time randomly selected 100 women with primary breast cancer who were under neoadjuvant chemotherapy. Detect the expression of CDK5RAP2 before and after neoadjuvant chemotherapy.
详细描述
The investigators selected 400 cases of women with primary breast cancer who were treated with operation randomly,then detect the expression of CDK5RAP2 of cancer tissue. At the same time randomly selected 100 women with primary breast cancer who were under neoadjuvant chemotherapy. Detect the expression of CDK5RAP2 before and after neoadjuvant chemotherapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Provision of informed consent
- •Pathological confirmation of breast cancer
- •Tumor stage(TNM):T2-4bN0-3M0
- •ER(+) and/or PR(+).
- •Premenopausal woman.
- •Age≥40 years
- •Measurable disease as per RECIST criteria
- •Karnofsky≥70
- •Laboratory criteria:
- •PLT≥100*109/L
- •WBC≥4000/mm3
- •HGB≥10g/dl
- •ALT and AST<2*ULN
排除标准
- •Presence of metastatic disease.
- •Inflammatory breast cancer.
- •Bilateral breast cancer.
- •previous chemotherapy or hormonal therapy for current breast neoplasm.
- •other malignant tumor (concurrent or previous).
- •Pregnant woman.
- •Hypersensitive to any drug in CEF regimen or any ingredient of Zoladex.
- •Any severe systemic disease contraindicating chemotherapy.
研究者
研究点 (1)
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