Somatic Symptoms in Autism Spectrum Disorder: Data Integration
试验速览
- 阶段
- 不适用
- 状态
- 进行中(未招募)
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- Patient health questionnaire-15, PHQ-15
研究概览
简要总结
Autistic patients have higher rates of co-morbid somatic symptoms. Thus, compared to the general population, they experience more health-related concerns, such as autoimmune disease, gastrointestinal disease, cardiovascular disease, and autonomic disorders. On average, an autistic patient's life span is 16 years shorter than that of a non-autistic patient. Furthermore, autistic patients are often unable to convey or communicate their somatic symptoms in a clear and comprehensive manner. This leads to a lack of proper health care provided in a timely manner.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 15 Years 至 70 Years(Child, Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ASD group: diagnosed with DSM-5 autism spectrum disorder
- •clinical group: anxiety, depression, somatic disorder who are non-psychotic and non-organic
- •control group: healthy control without psychiatric disorder or chronic somatic symptoms
- •age between 15 and 70
排除标准
- •psychiatric disorders such as schizophrenia, mood disorder.
- •major physical disorder which can be potentially lethal
- •who cannot read or comprehend the survey and questionnaire
研究组 & 干预措施
ASD
Diagnosed with DSM-5 autism spectrum disorder
干预措施: No intervention involved (Other)
Clinical
Patients with anxiety, depression, somatic symptoms which are non-psychotic and non-organic
干预措施: No intervention involved (Other)
Control
Healthy control without psychiatric disorder or chronic somatic symptoms
干预措施: No intervention involved (Other)
结局指标
主要结局
Patient health questionnaire-15, PHQ-15
时间窗: 8 years
range from 0 to 2 for each item, total score range from 0 to 30. Higher the score, worse the level of somatization
Health assessment questionnairse, HAQ
时间窗: 8 years
range from 0 to 3 for each item. Higher the score, worse the disability
Beck depression inventory, BDI
时间窗: 8 years
range from 0 to 3 for each item. Higher the score, worse the depression
Beck anxiety inventory
时间窗: 8 years
range from 0 to 3 for each item. Total score 0 to 63. Higher the score, worse the anxiety
Beck anxiety inventory
时间窗: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
range from 0 to 3 for each item. Total score 0 to 63. Higher the score, worse the anxiety
Tridimensional Personality Questionnaire (TPQ)
时间窗: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
a 100-item, true/false psychological test, measures three neurotransmitter-linked personality dimensions: 1. novelty seeking. High scores indicate individuals who are adventurous, easily bored, impulsive, and quick to react to new stimuli. Low Scores indicate individuals who are reflective, rigid, orderly, systematic, and comfortable with routine. 2. harm avoidance. High Scores: Indicates individuals who are cautious, fearful, socially inhibited, and prone to worry or depression.Low Scores: Indicates individuals who are confident, carefree, optimistic, relaxed, and resilient to stress. 3. reward dependence. High Scores: Indicates individuals who are warm, empathetic, socially sensitive, and highly motivated by praise.Low Scores: Indicates individuals who are independent, practical, socially detached, and emotionally self-sufficient.
WHO Quality of Life-BREF (WHOQOL-BREF)
时间窗: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
a 26-item survey by the World Health Organization that measures personal well-being across four core domains: physical health, psychological health, social relationships, and environment. Scores are scaled from 0 to 100, where higher numbers show a better quality of life.
Sensory profile
时间窗: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
a standardized questionnaire completed by caregivers, teachers, or individuals to evaluate how a person processes everyday sensory information (like touch, sound, and movement). It measures how a person's nervous system responds to sensory inputs and how those responses affect daily life. Results describe an individual in the following four areas: Seeking: Actively searches for extra sensory input (e.g., loves spinning, crashing into things, chewing objects, or loud music). Sensitivity: Detects sensory input very quickly and easily, noticing small details (e.g., easily distracted by background noise or bright lights). Avoiding: Actively tries to escape or prevent sensory input (e.g., covers ears in loud rooms, refuses certain clothing textures, or avoids crowds). Low Registration: Misses or is slow to notice sensory input (e.g., doesn't respond to their name, seems clumsy, or doesn't notice pain/temperatures).
Social responsiveness scale (SRS)
时间窗: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
a 65-item questionnaire that measures the severity of social impairment and autism spectrum-related traits. It evaluates how a person acts in real-life social settings. Higher scores represent greater impairment.
Autism Spectrum Quotient (AQ)
时间窗: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
The Autism Spectrum Quotient (AQ) is a 50-item self-report questionnaire used to measure autistic traits in adults and teens. Scores range from 0 to 50. A score of 26 or higher suggests elevated autistic traits, while 32 or higher indicates a strong presence of these traits.
Empathy Quotient (EQ)
时间窗: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
The Empathy Quotient (EQ) is a self-report questionnaire developed by psychologist Simon Baron-Cohen to measure a person's ability to understand others' thoughts and feel appropriate emotional responses. The standard test has 60 items (40 scored statements and 20 filler questions) spanning cognitive empathy, emotional reactivity, and social skills. Higher scores indicate higher empathy levels.
Patient health questionnaire-15, PHQ-15
时间窗: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
range from 0 to 2 for each item, total score range from 0 to 30. Higher the score, worse the level of somatization
Health assessment questionnaire, HAQ
时间窗: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
range from 0 to 3 for each item. Higher the score, worse the disability
Beck depression inventory, BDI
时间窗: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
range from 0 to 3 for each item. Higher the score, worse the depression
次要结局
未报告次要终点
