Vitamin D Metabolites as Biomarkers for the Identification of Kidney Injury in Cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- Determine the correlation between eGFR as determined serum creatinine and vitamin D metabolites as markers of kidney function
研究概览
简要总结
The investigators will be measuring vitamin D metabolites in blood samples drawn from patients undergoing cardiac surgery to determine the correlation with renal function as assessed by serum creatinine. The investigators will include 20 patients in each of the following 3 groups based on serum creatinine measured within 28-days of surgery: 1) normal kidney function (eGFR > 60 mL/min, n=20), 2) moderate impaired kidney function, eGFR between 30 and 60 mL/min (n=20) and 3) severe kidney dysfunction eGFR < 30 mL/min (n=20).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •≥ 18 years
- •Patients undergoing cardiac surgery
- •Serum Creatinine measured with 28 days of surgery
排除标准
- •Exogeneous calcitriol (1,25(OH)2D3) intake
- •History of parathyroidectomy
- •Patients with liver or kidney cancer
- •Patients with liver disease (e.g. liver failure, cirrhosis)
结局指标
主要结局
Determine the correlation between eGFR as determined serum creatinine and vitamin D metabolites as markers of kidney function
时间窗: Up to 1 month before surgery up until POD 7
serum creatinine (sCr) and vitamin D metabolites (specifically 25(OH)D3 and 1,25(OH)2D3) will be measured in the same blood sample to determine the incidence of AKI and CKD in patients undergoing cardiac surgery
次要结局
未报告次要终点