CTRI/2024/06/069352尚未招募Unknown
Role of serum Beta Hydroxy Butyrate levels in Doxorubicin and Cyclophosphamide induced neutropenia in breast cancer patients: A Pilot study - NI
DrNPKTeja Self0 个研究点目标入组 0 人开始时间: 待定最近更新:
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •All patients who have histopathologically confirmed breast malignancy and
- •Fit to receive Doxorubicin and Cyclophosphamide chemotherapy
- •Chemotherapy naive
- •Age above 18 years
- •Participants with
- •a.Haemoglobin above 8gm/dl,
- •b.Platelet count above 1,00,000/mm3
- •c.Absolute neutrophil count above 1500/ mm3
- •Patients with Left Ventricular Ejection Fraction more than 50%.
- •Participants with ECOG (Eastern Co-operative Oncology Group) performance status of 0-2.
排除标准
- •Not willing to provide informed consent
- •Participants with history of, use of drugs causing bone marrow toxicity like, Lamotrigine, Dapsone, Quinidine,Quinine, Propylthiouracil, Clozapine, Vancomycin in the past 2 months.
- •Patients with Chronic Kidney Disease with Creatinine clearance lesser than 30ml/min
- •Patients with Chronic hepatic disorders with Serum total Bilirubin greater than 5mg/dl and Transaminases (ALT & AST more than 5 times normal limit
- •Patients with refractory anaemia and with history of blood transfusions
- •Patients with Uncontrolled Diabetes Mellitus with HbA1c greater than or equal to 8% .
- •Diabetic patients receiving Insulin.
- •Patients who are on keto diet.
- •Participants with history of alcohol intake in the past 7 days.
- •Patients with known hypersensitivity to Doxorubicin or Cyclophosphamide.
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