The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Syndecan-1
研究概览
简要总结
Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx.
The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.
详细描述
The patients were allocated randomly to receive propofol or desflurane. Also, a total of 6ml of blood sample was obtained for total 6 times in consecutive order.
- Preoperation (immediate before anesthesia induction)
- Immediate before tourniquet off
- 5 min after tourniquet off
- PACU
- postoperative 6 hours
- postoperative 24 hours
Serum in blood will be obtained and level of serum cytokine will be evaluated by enzyme-linked immunosorbent assay
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who was planned to undergo knee surgery.
排除标准
- •age < 20 years old
- •history of previous cancer
- •history of previous peripheral vascular disease
- •Emergency surgery
研究组 & 干预措施
propofol group
The patient who anesthetized by using propofol.
干预措施: propofol group (Drug)
Desflurane group
The patient who anesthetized by using sevoflurane.
干预措施: Desflurane group (Drug)
结局指标
主要结局
Syndecan-1
时间窗: Preoperative time, Immediate before tourniquet off,5 min after tourniquet off,PACU, postoperation after 6hours, postoperation after 24hours
change of level of syndecan-1 (scores range from 0 to 100)
次要结局
未报告次要终点
研究者
Seong-Hyop Kim
Associate Professor
Konkuk University Medical Center