Impact of Phenylketonuria-type Diet on Appetite, Appetite Hormones and Diet Induced Thermogenesis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Appetite hormone: peptide YY (PYY)
研究概览
简要总结
Low-phenylalanine diets are commonly prescribed to people with phenylketonuria (PKU), an inborn disease which causes accumulation of amino acid phenylalanine (Phe) in the blood. High blood Phe levels can cause mental, behavioural, neurological, and physical problems. Thus, low-phenylalanine diets help patients to manage their condition but it is not clear whether they have an impact on appetite, energy intake and changes in body weight. This is important to explore as prevalence of obesity in this population is rising high. This study aims to find out the effect of PKU-type meals on appetite, appetite biomarkers, and post-meal energy expenditure. The investigators will recruit 26 healthy adults and ask them to participate in two experimental trials. On one occasion the participants will be asked to consume a PKU-supplemented drink followed by a PKU type-lunch and on another occasion the supplement and lunch will be based on normally consumed foods. Series of blood samples will be taken and appetite will be assessed during both experiments. Both experimental trials will finish with consuming an "all-you-can-eat" buffet.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adult
- •Body weight stable for previous 4 months
- •Regular menstrual cycle (females)
排除标准
- •Pregnancy or lactation (females)
- •History of eating disorder
- •History of gastrointestinal problems or surgery
- •History of allergy
- •History of chronic illness
- •On any medication
- •On nutritional supplements
- •Following specific diet
- •Currently taking part in other research
结局指标
主要结局
Appetite hormone: peptide YY (PYY)
时间窗: 300 minutes
Plasma concentration at baseline (0 minute) and after ingestion of supplement (at 30, 60 and 90 minutes) and lunch (at 120, 150,180, 210, 240, 270 and 300 minutes)
Appetite hormone: glucagon-like peptide-1 (GLP-1)
时间窗: 300 minutes
Plasma concentration at baseline (0 minute) and after ingestion of supplement (at 30, 60 and 90 minutes) and lunch (at 120, 150,180, 210, 240, 270 and 300 minutes)
Appetite hormone: ghrelin
时间窗: 300 minutes
Plasma concentration at baseline (0 minute) and after ingestion of supplement (at 30, 60 and 90 minutes) and lunch (at 120, 150,180, 210, 240, 270 and 300 minutes)
Subjective appetite score
时间窗: 300 minutes
Visual analogue scale (VAS) collected at baseline and after each blood sample collection
Appetite hormone: insulin
时间窗: 300 minutes
Plasma concentration at baseline (0 minute) and after ingestion of supplement (at 30, 60 and 90 minutes) and lunch (at 120, 150,180, 210, 240, 270 and 300 minutes)
Diet induced thermogenesis
时间窗: 300 minutes
Metabolic rate by means of computerised open-circuit ventilated hood system collected at baseline and after each blood sample collection for the duration of 20 minutes
Appetite hormone: cholecystokinin (CCK)
时间窗: 300 minutes
Plasma concentration at baseline (0 minute) and after ingestion of supplement (at 30, 60 and 90 minutes) and lunch (at 120, 150,180, 210, 240, 270 and 300 minutes)
次要结局
- Taste perception of PKU supplements/foods(10 minutes)
- Consumption time for PKU supplements/foods(20 minutes)
研究者
Dr Dalia Malkova
Senior Lecturer
University of Glasgow