Comparative Study Between Different Modes of Ventilation During Cardiopulmonary Bypass and Its Effect on Postoperative Pulmonary Dysfunction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- lung ultrasonography
研究概览
简要总结
66 patients divided into 3 groups with different modes of ventilation.
详细描述
Sixty-six patients going through open-heart surgeries were included in the study, divided into 3 groups (P: pressure controlled ventilation, V: volume controlled ventilation, C: control) in accordance with the mode of ventilation. Patients studied for chest x-ray, lung ultrasound, arterial oxygen partial pressure to fractional inspired oxygen ratio (PaO2/FiO2), Alveolar-arterial oxygen gradient, static lung compliance and dynamic lung compliance, taken after induction of anesthesia, 1h post cardiopulmonary bypass, 1h after arrival to cardiac surgical unit.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoingvalve surgeries
- •Patients undergoing coronary artery bypass grafting surgeries
排除标准
- •Emergency cases.
- •Off-pump surgeries.
- •Patients with chronic lung diseases with forced expiratory volume in first second (FEV1) or forced vital capacity (FVC) less than 40% of the predicted value.
- •Massive blood transfusion during surgery.
- •Complicated surgeries.
- •Redo surgeries.
- •Patients with decompensated heart failure prior to surgery.
- •Patients refusal
研究组 & 干预措施
No ventilation
During cardiopulmonary bypass period the patients were disconnected from ventilator
Volume-controlled ventilation
During cardiopulmonary bypass period the patients were ventilated with volume-controlled ventilation
干预措施: Volume controlled ventilation (Device)
Pressure-controlled ventilation
During cardiopulmonary bypass period the patients were ventilated with pressure-controlled ventilation
干预措施: Pressure controlled ventilation (Device)
结局指标
主要结局
lung ultrasonography
时间窗: after induction of anesthesia, 1hour post cardiopulmonary bypass and 1hour after arrival to cardiac surgical unit.
Lung ultrasonography to detect any lung changes from baseline or development of consolidation, pulmonary edema or pleural effusion
chest x-ray
时间窗: after induction of anesthesia, 1hour post cardiopulmonary bypass and 1hour after arrival to cardiac surgical unit.
Chest x ray to detect any lung pathology or changes from baseline like pleural effusion, pulmonary edema or pneumonia
次要结局
未报告次要终点
研究者
Ayman Anis Metry
Assistant professor
Ain Shams University