Towards a Better Classification of Respiratory Amyloidosis. Contribution of Proteomic Analysis Based on Tandem Mass Spectrometry
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 70
- 主要终点
- Number of cases with identification of the amylogenic protein in respiratory amyloidosis.
研究概览
简要总结
The B-AR project is based on a retrospective analysis of amyloidosis typing and the identification of their amylogenic protein.This work should be able to unite many clinicians, including pulmonologists and pathologists around a rare disease that still suffers from insufficient data.
详细描述
The B-AR study will highlight the interest of proteomic analysis of amyloidosis compared to their identification by immunostaining. The objective is to reduce diagnostic wandering and to improve patient management. The typing of respiratory amyloidosis will allow a better characterization of the disease and thus, to propose a dedicated therapeutic management.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patient > to 18 years with amyloidosis on a histological sample of the tracheobronchial or pulmonary tree.
排除标准
- •Subject receiving state medical aid
- •Subject deprived of freedom, or under a legal protective measure (example: patients under guardianship or curators)
结局指标
主要结局
Number of cases with identification of the amylogenic protein in respiratory amyloidosis.
时间窗: 1 day (at inclusion)
Identification of amylogenic protein by Proteomic Analysis Based on Tandem Mass Spectrometry on histological sample of the tracheobronchial or pulmonary tree.
次要结局
- Distribution and severity of amyloidosis(1 day (at inclusion))