Diagnosis and Treatment of Non-communicable Diseases and Geriatric Syndromes in the HIV Aging Population in Sub-Saharan Africa
试验速览
- 阶段
- 不适用
- 入组人数
- 500
- 主要终点
- Change in proportion of participants with any non communicable disease
研究概览
简要总结
The overall goal of the proposal is to improve capacity for detection and management of non-communicable diseases and geriatric syndromes in the aging HIV population in sub-Saharan Africa
详细描述
The establishment and scale up of solid and sustainable HIV programs in sub-Saharan Africa (SSA) has led to a reduction in mortality and morbidity from HIV related opportunistic infections and some HIV related cancers. This improved survival has resulted in two phenomena: the first is the surfacing of non-communicable diseases (NCDs) in the HIV population, especially in those on long-term ART, and the second is increased longevity leading to increasing numbers of elderly HIV infected individuals
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 60 years and above
- •Evidence of a personally signed and dated informed consent document indicating that the subject (or a legal representative) has been informed of all pertinent aspects of the study.
- •Subjects who are willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures.
排除标准
- •Any clinical (physical and psychiatric) condition which prevents the patients to participate safely in the study procedures according to the judgments of a physician.
- •Subjects already enrolled in experimental clinical trial.
结局指标
主要结局
Change in proportion of participants with any non communicable disease
时间窗: Enrollment, year 1, year 2
Proportion with any non communicable disease (including hypertension, cardio vascular disease, respiratory disease, renal disease, non HIV related cancers, frailty)
Change in Quality of life
时间窗: Enrollment, year 1, year 2
Quality of life measured using the WHO Quality of life for elderly (WHOQOL-OLD)
次要结局
- Change in proportion of patients with polypharmacy monitoring(Enrollment, year 1, year 2)
- Change in Nutritional status assessed by Mini Nutritional Assessments (MNA)(Enrollment, year 1, year 2)
- Change in proportion of patients with disability(Enrollment, year 1, year 2)
- Change in proportion of patients with history of falls(Enrollment, year 1, year 2)
- Change in proportion of patients with urinary incontinence measured by ICIQ-UI Short(Enrollment, year 1, year 2)
- Change in proportion of patients with depression(Enrollment, year 1, year 2)
- Change in proportion of patients with cognitive deficit(Enrollment, year 1, year 2)