Correlative Factors of Cognitive Dysfunction in Patients With Cancer Pain: a Cross-sectional Study From China
试验速览
- 阶段
- 不适用
- 入组人数
- 928
- 试验地点
- 1
- 主要终点
- Prevalence of Cancer-related cognitive dysfunction patient with pain
研究概览
简要总结
To investigate the occurrence of cognitive dysfunction in cancer patients with pain in China.Analysis of patients with different cancer pain, different analgesic drugs and different treatments are associated with the severity of cognitive dysfunction, to provide relevant evidence for the next screening, prediction, prevention and treatment. In order to achieve the purpose of improving the quality of life of cancer patients.
详细描述
Cross-sectional survey in patients with cancer pain is used in the outpatient clinics and wards of five cancer hospitals in China.
This study is to survey the incidence of cognitive dysfunction in Chinese cancer patients, and the related factors of cognitive dysfunction, demographic characteristics (economic situation, education, gender, age), disease status (tumor type, staging) ), analgesic treatment (NRS score, with or without analgesic drugs, analgesic drug name, dose), anti-tumor treatment (with or without anti-tumor treatment, surgery, radiotherapy, chemotherapy, time interval from last treatment, chemotherapy drugs) and so on.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Malignant tumor patient with pain are confirmed by histopathology or cytology (NRS score ≥ 1);
- •Understand Chinese through verbal and written communication, read and write Chinese, numbers, and complete questionnaire surveys;
- •Male or female, age 18-75 years old;
- •ECOG 0-2, expected to survive for more than 3 months;
- •no obvious dysfunction of heart, lung, liver, kidney, blood system (≤I degree);
- •patients voluntarily sign informed consent
排除标准
- •Pregnant women and lactating women.
- •Also participate in clinical trials of drugs that have not been approved for marketing.
- •Patients with depression (evaluated by the Hamilton Depression Scale).
- •Active bleeding or bleeding tendency.
- •Serious or uncontrolled medical conditions and infected people.
- •Patients with structural heart disease, such as coronary heart disease, unstable angina, especially patients with congestive heart failure and atrial fibrillation, atrial flutter history, and patients with hypertension, hypercoagulable state and severe cerebrovascular disease.
- •History of thromboembolic disease; long-term oral administration of aspirin and other anticoagulants.
- •Preventive Whole Brain Irradiation (PCI).
- •Bone marrow invasion or bone marrow metastasis.
- •Patients with severe or uncontrollable mental illness.
结局指标
主要结局
Prevalence of Cancer-related cognitive dysfunction patient with pain
时间窗: 6 months
Statistical analysis was performed SPSS 21.0. The t test was used for comparison between groups, and the X2 test was used for the count data. The logistic regression model was used for multivariate analysis. The regression coefficient, P value and OR value were calculated by age, ethnicity, education level, treatment plan and income as covariates.
次要结局
未报告次要终点