Rituximab as Second Line Treatment for ITP; A Multicenter, Randomized, Double Blind, Placebo-controlled, Phase III Study. "The RITP Study"
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 112
- 试验地点
- 1
- 主要终点
- The primary endpoint is treatment failure as defined by a composite end point of Splenectomy performed at any time after randomization or Meeting the predefined Criteria for Splenectomy at or after week 12 that is if splenectomy is not performed.
研究概览
简要总结
Immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized thrombocytopenia.
Splenectomy is the standard treatment for patients who fails the first-line treatment: corticosteroid. Rituximab, has recently emerged as a promising treatment for ITP. The aim of the study is to determine whether early treatment with Rituximab can result in durable remissions, and consequently, lead to the avoidance of splenectomy in a significant number of patients.
详细描述
ITP is an autoimmune disorder characterized by formation of autoantibodies against platelet antigens leading to premature platelet destruction and persistent thrombocytopenia often resulting in bleeding.
The goal of treatment is to raise the platelet count to a hemostatically safe level.
Treatment with corticosteroids rarely results in durable responses, and most of the patients will ultimately require a second-line treatment. Splenectomy results in a high rate of sustained remissions. However, the procedure is invasive and is associated with considerable short and long term morbidity and mortality. Rituximab, a chimeric anti-CD20 antibody with a B-cell depleting effect, has recently emerged as a promising treatment for ITP.
The study aims to determine whether early treatment with Rituximab can result in durable remissions, and consequently, avoidance of splenectomy in a clinical significant number of patients.
The main objective of this study is to assess the rate of treatment failure (splenectomy or meeting criteria for splenectomy after week 12) at 1.5-year in a prospective, randomized, placebo-controlled, double-blind, multi-centre
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ITP with platelet count <30 x 109 /l after 2 weeks of treatment with prednisolon or during prednisolon tapering period i.e. from week three of prednisolon initiation. Patients with platelet count between 30 -50 are eligible if a higher platelet count is considered necessary, because of : concomitant medical illness predisposing to bleeding (hypertension, GI bleeding, bleeding diathesis, previous history of bleeding) concomitant medical condition requiring platelet blocking agents/ anticoagulation, persistent bleeding despite platelets > 30 x 109 /l, prior to surgery, or because of other patient related factors necessitating higher platelet count as occupation, hobby, psychological intolerability.
- •Subject is >18 years
- •Subject has signed and dated written informed consent.
- •Subject is able to understand and comply with protocol requirements and instructions, and intends to complete the study as planned.
- •Females in fertile age should express willingness for use of contraceptive means for 6 months following the administration of the study drugs.
- •Exclusion criteria:
- •Previous splenectomy, chemotherapy, treatment with anti-D Ig, rituximab, or immune-suppressive treatments other than corticosteroids, Dapsone or Danazol
- •Underlying malignancy or previous history of malignancy in the past 5 years (except skin carcinoma)
- •Pregnancy and lactation
- •Not willing to participate in the study
- •Expected survival of < 2 years
- •Known intolerance to murine antibodies
- •Females in child-bearing age not willing to use contraception for 6 months
- •HIV-positive/AIDS-, Hepatitis -B virus positive- or Hepatitis -C virus positive
- •Patients with a definite Systemic Lupus Erythematosus (SLE) (> 4 of the American College of Rheumatology Criteria)
- •Patients currently involved in another clinical trial with evaluation of drug treatment
- •Bacterial infections, viral infections, fungal infections, myco-bacterial infections (excluding fungal infections) or other evolutive infections or any other infections episode requiring hospitalisation or treatment with an antibiotics 4 weeks before selection for IV route or within 2 weeks before selection for oral route
- •History of soft tissue, bone or joint infections (fascitis, abscess, osteomyelitis, septic arthritis) during the last year prior to inclusion in the study
- •Medical history of relapsing or chronic severe infectious diseases or any other underlying pathology predisposing to serious infections
- •Known Primary or secondary immune deficiency syndromes
- •Administration of a living vaccine within 4 weeks preceding the inclusion in the study -16- Previous treatment with any lymphocytes depleting medication (e.g.: MabCampath®)
- •17- Previous treatment with inhibitors of leucocytes transmigration (e.g.: Tysabri®) 18- Known intolerance to human monoclonal antibodies 19- Known severe chronic pulmonary obstructive Disease (FEV < 50% or functional dyspnoea grade 3) 20- Known congestive heart failure NYHA (New York Heart Association classification of heart failure) class III and IV 21- Recent episode (<6 months) of acute coronary syndrome.
排除标准
- 未提供
研究组 & 干预措施
Rituximab
I.V infusion of Rituximab 375 mg/m2 per week for 4 weeks
干预措施: Rituximab (Mabthera) (Drug)
Placebo
I.V infusion of NaCl 0.9%
干预措施: Rituximab (Mabthera) (Drug)
结局指标
主要结局
The primary endpoint is treatment failure as defined by a composite end point of Splenectomy performed at any time after randomization or Meeting the predefined Criteria for Splenectomy at or after week 12 that is if splenectomy is not performed.
时间窗: 1.5 years
次要结局
- Response rates(1.5 years)
- Relapse rate(1.5 years)
- Mortality rate(1.5 years)
- Complications rate(1.5 years)
研究者
Waleed Ghanima
Dr Waleed Ghanima, MD. PhD
Ostfold Hospital Trust