Influence of Autonomy on Motor Learning in People With Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 72
- 试验地点
- 2
- 主要终点
- Performance accuracy
研究概览
简要总结
The goal of this clinical trial is to explore the benefits of autonomy supported learning in patients with Parkinson's disease. The main questions to answer are:
- Whether autonomy supported learning can benefit motor learning in PD patients
- Whether autonomy supported learning can enhance intrinsic motivation and/ or information processing of PD patients in learning a new task.
- Whether autonomy supported learning can facilitate cortical excitability change after practicing a new task.
Participants will be recruited into two groups (Self-control group, SC; and yoked group, YK) to learn a finger-pressing trajectory matching task
- Participants in SC group will have choice over feedback schedule during trial practice
- Participants in YK group will receive feedback with no-choice during trial practice Researchers will compare the retention test performance to see if autonomy supported learning will lead to better learning effect.
详细描述
Autonomy is the sense of learner to actively participate in determining their own behaviour. The present study aims to investigate whether an autonomy supported practice (with self-controlled feedback) would benefit adults with Parkinson's disease (PD), along with increased intrinsic motivation, information processing and cortical excitability. Two groups of healthy adults and two groups of PD patients will be recruited to learn a finger-pressing trajectory matching task. Participants will be allocated in either a self-control group (choice over feedback schedule), or a yoked group (receive feedback with no-choice). Learning will be assessed on the second day and one week later, along with an error estimation of learners' own performance to represent their information processing ability. Cortical excitability and inhibition will be assessed via transcranial magnetic stimulation as indicators of cortical plasticity. Questionnaire regarding motivation will be assessed before and after practice trials. Study hypothesized that individual with PD would benefit from autonomy supported learning, with better performance, enhanced motivation and information processing, associates with change of cortical excitability
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age above 20-years-old
- •able to follow instructions to perform the tasks (Montreal Cognitive Assessment ≥ 24)
- •no surgery and injury in upper extremities in recent 6 months
排除标准
- •other neurological disorders in addition to Parkinson's disease
- •Parkinson's disease dementia
- •symptom of severe tremor in upper extremities (score ≥ 3 in Question 15 to 18 of UPDRS-III)
- •deep brain stimulation or pacemaker implanted
- •medical history of seizure
- •a blood-relative with history of epilepsy
- •unstable medical conditions
- •pregnancy
结局指标
主要结局
Performance accuracy
时间窗: up to day 7
Overall performance accuracy relative to the target waveform was assessed using root mean square error (RMSE), which is the mean difference between the target waveform and the participant's movement trajectory calculated over their actual movement time.
次要结局
- Intrinsic Motivation Inventory(day 1, day 2, day 7)
- Error Estimation(day 2, day 7)
- Cortical excitability changes(Baseline, day 2, day 7)