The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 120
- 试验地点
- 3
- 主要终点
- coronary artery calcium score
研究概览
简要总结
Individuals with rheumatoid arthritis (RA) have up to 2x the risk of having a heart attack compared to someone without RA. The goal of this study is to identify biomarkers that can help us do a better job of identifying individuals at risk before they develop symptoms of heart disease and start preventative treatment earlier.
详细描述
The objective of this study is to test the utility of high sensitivity cardiac troponin (hs-cTn) and coronary artery calcium (CAC) in risk stratifying patients with rheumatoid arthritis (RA) who may benefit from lipid lowering therapy. The population of interest are individuals who would not otherwise be recommended for therapy based on general population risk calculators for heart disease risk.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 35 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •RA diagnosed by a rheumatologist
- •Age 40- 79
- •≥1 ASCVD risk factor including prediabetes, hypertension, BMI >30, current or history of cigarette smoking
排除标准
- •Patients on a statin or with a contraindication to statin, on a cholesterol absorption inhibitor, or on a PCSK9 inhibitor
- •Patients with diabetes mellitus
- •Pregnancy
结局指标
主要结局
coronary artery calcium score
时间窗: Cross-sectional, at baseline
Quantified coronary artery calcium score
次要结局
未报告次要终点
研究者
Katherine P Liao
Associate Professor of Medicine
Brigham and Women's Hospital