The Impact of Lymphaticovenous Anastomosis on Serum Profiling in Patients With Lymphedema
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- the correlation between post-LVA volume reduction
研究概览
简要总结
The correlation between oxidative stress and increased lymphedematous limb volume lacks supporting evidence. Lymphedema patients are prone to cellulitis. This study aims to investigate the link between oxidative stress, limb volume, and cellulitis after supermicrosurgical lymphaticovenous anastomosis (LVA).
详细描述
In this study, we focused on the changes in serum antioxidant biomarkers before and after LVA, detected by isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomic analysis, enzyme-linked immunosorbent assay (ELISA), and Oxidative Stress Panel Kit. For clinical correlation, magnetic resonance (MR) volumetry was implemented for precise lymphedematous limb volume measurements. Correlations were made between changes in oxidative stress, limb volume, and cellulitis before and after LVA.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with lower limb lymphedema confirmed with lymphoscintigraphy
- •unilateral lower limb lymphedema
- •lymphedema duration > 2 years
- •no active infection
- •no prophylactic antibiotic use for at least one month before LVA
- •no tumor recurrence or metastasis
- •no consumption of antioxidants, such as vitamin E or ascorbic acid
排除标准
- •Patients with upper limb and bilateral lower limb lymphedema
结局指标
主要结局
the correlation between post-LVA volume reduction
时间窗: 6 months after surgery
The primary outcome was determined whether post-LVA volume reduction \< 40%
次要结局
未报告次要终点