Comparison of the Glasgow Blatchford Score, AIMS65, and Pre Endoscopic Rockall Score in Predicting Outcomes of Upper Gastrointestinal Bleeding at a Tertiary Care Centre
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Requirement for Blood Transfusion Within 24 Hours
研究概览
简要总结
The goal of this prospective observational study is to compare the Glasgow-Blatchford Score (GBS), AIMS65, and pre-endoscopic Rockall Score in predicting outcomes among patients with upper gastrointestinal bleeding (UGIB). The main questions it aims to answer are:
Which score best predicts in-hospital mortality and need for clinical intervention? Which score best predicts rebleeding and length of hospital stay?
Researchers will compare the predictive performance of the three scoring systems. Participants will have their clinical and laboratory data collected and will be followed during their hospital stay for relevant outcomes.
详细描述
Upper gastrointestinal bleeding (UGIB) is a common medical emergency associated with significant morbidity and mortality. Early risk stratification is essential to guide timely intervention, prioritize endoscopy, optimize resource allocation, and identify low risk patients suitable for conservative or outpatient management. Several pre-endoscopic scoring systems, including the Glasgow-Blatchford Score (GBS), AIMS65, and the pre endoscopic Rockall Score, are commonly used; however, their their comparative performance varies across populations, and local data from Nepal remain limited.
This prospective observational study aims to compare the predictive accuracy of GBS, AIMS65, and pre-endoscopic Rockall Score in patients presenting with upper gastrointestinal bleeding at a tertiary care hospital in Nepal over a six-month study period. The primary outcomes will include in-hospital mortality and need for clinical intervention (blood transfusion, endoscopic therapy, surgery, or ICU admission). Secondary outcomes will include rebleeding and length of hospital stay. Predictive performance will be evaluated using receiver operating characteristic curve analysis.
The findings of this study are expected to identify the most appropriate pre-endoscopic risk stratification tool for UGIB in the Nepalese context, thereby supporting early clinical decision-making and improving patient management.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥16 years.
- •Presenting with acute UGIB (hematemesis, melena, or hematochezia).
- •Patients providing informed written consent.
排除标准
- •Patients with lower gastrointestinal bleeding or uncertain source of bleeding.
- •Patients with prior UGIB within the last 30 days.
- •Patients refusing consent.
- •Patients who are lost to follow-up before assessment of primary outcomes.
结局指标
主要结局
Requirement for Blood Transfusion Within 24 Hours
时间窗: Within 24 hours of hospital admission
Proportion of participants requiring blood transfusion (packed red blood cells or Whole blood) within 24 hours of presentation.
Rate of Intensive Care Unit (ICU) Admission
时间窗: through study completion, an average of 7 days
Proportion of participants requiring admission to the ICU due to severe upper gastrointestinal bleeding or hemodynamic instability.
次要结局
- In-Hospital Rebleeding Rate(through study completion, an average of 7 days)
- Early Mortality (Within 48 Hours)(Within 48 hours of hospital admission.)
- Overall In-Hospital Mortality(through study completion, an average of 7 days)
研究者
Prajwol Neupane
Medical Officer
Kathmandu Medical College and Teaching Hospital