O-GlcNac Modified Proteomics Study of the Maturation of Hemodialysis Arteriovenous
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 126
- 试验地点
- 1
- 主要终点
- The diameter of each passage of the passage vein (forearm head vein) of the arterial and venous access within three months
研究概览
简要总结
We divided into three parts to carry out. Firstly, evidence the pre-existing fibrosis in vein of AVF failure patients. investigation of expression, the role, and the mechanism by which the identified O-GlcNAac proteins promote, maturation of AV fistula. Finally, ddress and compare the proteomics differentiation between failure and maturation of AVF patients.
详细描述
End stage renal disease (ESRD) patients requires hemodialysis to maintain bloodstream functions. Before the hemodialysis, the patients requires a long-term vascular access, which best choice is Arteriovenous fistulas (AVF). However, 1/3 of patients were failure in AVF maturation, and it is still unknown. Our preliminary data have shown that pre-exisiting fibrosis in vein of AVF failure. Here, we will investigate whether pre-existing fibrosis of vein is asssociated with circulating fibrocytes in AVF failure, and further to address molecular mechanism of fibrocytes differentiation. We will divide into three parts to carry out. Firstly, evidence the pre-existing fibrosis in vein of AVF failure patients. Secondary, investigation of expression, the role, and the mechanism by which the identified O-GlcNAac proteins promote, maturation of AV fistula. Finally, address and compare the proteomics differentiation between failure and maturation of AVF patients. We hope that through this project, we can obtain signifiture molecules for precision detection and solve the current clinical unmet need.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age of 20 and older adult patients, and preoperatively clinical and ultrasound assessment of the arm vessels are fisible for the creation of a native HDAVF that include:the augmented diameters of the veins is > 2.0 mm and the diameter of the radial artery is> 2.0 mm. Besides, there is no obvious stenosis of vessels in the forearm.
排除标准
- •The patient refused to join the study
- •Serious heart failure
- •Unconsciousness
- •Bedridden for long time
- •systemic lupus erythematosus(SLE), or other known autoimmune diseases
- •The physician excludes the possibility of creating a wrist HDAVF before surgery
- •Surgeon preoperatively identifies vessel inadequacy for the creation of a wrist HDAVF
- •Choose a site other than the wrist for surgery
- •Unexpected negative complications happen during surgery that prevent the completion of a wirst HDAVF
结局指标
主要结局
The diameter of each passage of the passage vein (forearm head vein) of the arterial and venous access within three months
时间窗: Postoperative Three months
Comparison of the various methods to achieve within three months the checkpoint path diameter increase rate (two time points measurement difference).
次要结局
未报告次要终点