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临床试验/NCT02280369
NCT02280369已完成不适用

Posture Detection for Automated Abdominal Binder

Vanderbilt University1 个研究点 分布在 1 个国家目标入组 21 人开始时间: 2014年9月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
21
试验地点
1
主要终点
Percentage of times the thigh and waist accelerometer sensors correctly detect upright posture.

研究概览

简要总结

The automated inflatable abdominal binder is an investigational device for the treatment of orthostatic hypotension (low blood pressure on standing) in autonomic failure patients. The purpose of this study is to evaluate the performance of the binder in detecting body posture during different types of human motion patterns and activities of daily living, and to develop new (and better) ways to detect upright posture. In particular, the investigators want to determine if activities of daily living, normally encountered by patients (lying down, sitting, standing, walking, and climbing up and down steps), interfere with the detection of upright posture used to trigger the device. Studies will be conducted in healthy subjects because the main purpose of this study is to evaluate posture detection rather than treating orthostatic hypotension.

详细描述

The Primary Objective of this study is to develop and validate the algorithm needed to detect upright posture with a waist 3-axis accelerometer. A Secondary Objective is to determine the performance reliability of posture detection of the thigh and waist accelerometers when exposed to activities of daily living (standing, walking, climbing stairs). We will test the primary and secondary objectives in normal subjects using a single study design. Studies for both objectives will be conducted simultaneously on each subject on a single study day. Normal subjects will wear a device with the waist accelerometer incorporated within the controller box.

Subjects will be instrumented with the abdominal belt and controller box containing the waist accelerometer sensor. The external accelerometer sensor will be fixed with a Velcro around the thigh. In addition, subjects will wear two commercially available accelerometer sensors: 1) the ActivPal on the thigh of the other leg, and 2) an external accelerometer attached to the back of the belt at the level of the waist. The ActivPal can detect the upright posture but cannot distinguish between supine and sitting. The sensor placed on the back will be less affected by belly size in case of obese subjects. Both sensors will be used as a reference and for comparison. We will record all accelerometer signals during different body positions and activities. The activities will include lying down, sitting, getting up and standing still, walking, and climbing up and down steps for about one minute each for a total of 15-20 minutes per group of activities. Participants will perform 3 groups of activities. The order of activities within each group will be randomized. We might also ask you to perform ~3 small jumps to synchronize the sensors at the beginning, middle and the end of each set of activities.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Cross Sectional

入排标准

年龄范围
21 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Body mass index <30 Kg/m
  • Able and willing to provide informed consent.

排除标准

  • Pregnancy.
  • Any major medical problems or systemic illnesses known to produce orthostatic intolerance.
  • Other factors which in the investigator's opinion would prevent the subject from completing the protocol including clinically significant abnormalities in clinical, mental or laboratory testing during the screening

结局指标

主要结局

Percentage of times the thigh and waist accelerometer sensors correctly detect upright posture.

时间窗: during 5-10 minutes performing each activity (lying down, sitting, standing, climbing steps, walking)

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Italo Biaggioni

Professor of Medicine and Pharmacology

Vanderbilt University

研究点 (1)

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