Perioperative metformin treatment for colon cancer - a randomized trial - MECORA

Ismail Gögenur0 个研究点目标入组 48 人开始时间: 2017年5月8日最近更新: 2021年10月18日

适应症

试验速览

暂无简介。

•-Patients with adenocarcinoma of the colon planned for elective curative intended surgery at Slagelse hospital
•-Age of 18 or above
•-Must be able to understand and sign informed content
•-Sufficient amount of representative tumor material from the biopsies taken at the initial colonoscopy must be present
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 15
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 33

•-Patients diagnosed with diabetes mellitus
•-Patients who are receiving or have received metformin or other oral antidiabetics
•-Impaired kidney function (eGFR < 60mL/min)
•-Severe liver disease (defined as transaminases above X 3 normal levels)
•-Participation in another pharmacological intervention trial
•-Predictable poor compliance (for instance not speaking fluent Danish, mentally impaired)
•-Presenting with metastatic disease
•-Patients undergoing neoadjuvant chemotherapy
•-Pregnancy or lactation (fertile women must have a negative serum or urine pregnancy test to participate)
•-Fertile women who do not use safe contraception during the study period.

发起方

Ismail Gögenur