Identification of miRNAs in Endometrial Cancer as Novel Diagnostic and Prognostic Biomarkers
试验速览
- 阶段
- 不适用
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Evaluation of miRNA expression based on the 4 molecular groups
研究概览
简要总结
The TCGA project identified four distinct prognostic groups of endometrial carcinoma (EC) based on molecular alterations: (i) the ultramutated subtype that encompasses POLE mutated (POLE) cases; (ii) the hypermutated subtype, characterized by MisMatch Repair deficiency (MMRd); (iii) the copy-number high subtype, with p53 abnormal/mutated features (p53abn); (iv) the copy-number low subtype, known as No Specific Molecular Profile (NSMP). Although the prognostic value of TCGA molecular classification, NSMP carcinomas present a wide variability in molecular alterations and biological aggressiveness. Given that the study aims to evaluate the miRNA expression profile to identify novel potential biomarkers to better stratify the EC patients, taking into account the molecular status
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •age>18yo
- •histological diagnosis of endometrial cancer
- •tumor resection
- •patient's informed consent
排除标准
- •patients with other neoplasia within the last 5 years
结局指标
主要结局
Evaluation of miRNA expression based on the 4 molecular groups
时间窗: 1 year
Evaluate miRNA expression based on the 4 molecular groups recently identified
次要结局
- Integration of molecular results with clinico-pathological data(1 year)
研究者
Anna Myriam Perrone
Principal investigator
IRCCS Azienda Ospedaliero-Universitaria di Bologna