Biocollection on Peripheral Inflammation in Psychiatric Pathologies
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Demonstration of the presence of diagnostic biomarkers and biomarkers of severity common to several psychiatric disorders.
研究概览
简要总结
Most psychiatric research is based on the nosographic classifications used in current practice. At present, there is no diagnostic or prognostic biomarker for psychiatric pathologies commonly used in clinical practice. The study hypothesis is that peripheral inflammatory biomarkers could be common to several psychiatric disorders, in particular psychotic disorders (bipolar disorder, schizophreniform disorder, schizophrenia, depressive episode with psychotic features). The aim of this project is to set up a bio-collection of biological samples (peripheral blood samples) with associated phenotypic data (assessment of various symptoms using standardized scales in patients whose blood is sampled). The setting up of this cohort follows on from work carried out on a PsyCourse cohort also using a transdiagnostic approach in psychiatry, in order to be able to collaborate within a European research project.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Major patient
- •Patient with one of the following diagnoses confirmed by a psychiatrist:
- •Characterized depressive episode with psychotic features,
- •Bipolar disorder type I
- •Bipolar disorder type II
- •Schizoaffective disorder
- •Schizophrenia
- •Schizophreniform disorder
- •Patient under psychiatric care at Nantes University Hospital
- •Patients weighing at least 45kg
- •Patient affiliated to a social security scheme or beneficiary of such a scheme
- •Patient who has given informed consent to participate in the study
排除标准
- •Pregnant,
- •History of cancer in the last 5 years,
- •Vaccination within the last 4 weeks,
- •Acute or chronic infection,
- •Medical history of organ transplant,
- •Medical history of autoimmune disease,
- •Hearing impairment making it impossible to complete study questionnaires,
- •Patient under court protection
结局指标
主要结局
Demonstration of the presence of diagnostic biomarkers and biomarkers of severity common to several psychiatric disorders.
时间窗: 2 hours
Biological analysis of IBIS-PSY biocollection samples
次要结局
- Comparison of biomarkers between different psychiatric illnesses in order to develop models based on biological data that can help the physician adjust the diagnosis(2 hours)
- Validation of a patient clustering method separating patients with severe symptoms from those with mild symptoms(2 hours)
- Replication of a pan-transcriptomic study (A Transcriptome-Wide Association Study (TWAS))(2 hours)