A clinical study of Rheumatoid Arthritis with special reference to lipid profile abnormalities and its correlation with disease activity
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- 1) TO ASSESS THE CLINICAL PROFILE OF PATIENTS WITH RHEUMATOID ARTHRITIS AND THEIR DISEASE ACTIVITY USING DAS 28 CRITERIA AT PRESENTATION
研究概览
简要总结
Rheumatoid arthritis is a common autoimmune disease characterised by inflammatory arthritis.Rheumatoid arthritis is primarily considered a disease of the joints but abnormal immune responses are evident and can cause a variety of extra articular manifestations such as vasculitis, nodules and accelerated atherosclerosis. It has been observed that rheumatoid arthritis patients have greater rate of cardiovascular mortality and morbidity. Dyslipidemia is highly prevalent in RA and appears to be present very early in the RA disease process. Apart from the usual risk factors , chronic inflammatory state and dyslipidemia have been proposed as the reasons for accelerated premature atherosclerosis in RA leading to an increased risk for cardiovascular disease. Most studies have shown that the lipid profile of patients with active or untreated RA is primarily characterised by a decrease in the serum levels of HDL cholesterol. The significant reduction in HDL increases the total cholesterol by HDL ratio which represents the atherogenic index and this could explain the increased coronary artery disease risk in these patients. Reduction in HDL also correlated with the disease activity suggesting a potential role for inflammation in the atherogenic risk observed in RA.
This study aims to evaluate the lipid profile abnormalities in patients of Rheumatoid arthritis and its correlation with disease activity.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •RHEUMATOID ARTHRITIS PATIENTS OF BOTH GENDER FULFILLING THE AMERICAN COLLEGE OF RHEUMATOLOGY CRITERIA 2010 FOR RHEUMATOID ARTHRITIS.
排除标准
- •MALABSORPTION SYNDROME, NEPHROTIC SYNDROME, CHRONIC KIDNEY DISEASE, DIABETES MELLITUS, THYROID DISORDERS,LIVER DISORDERS, HEREDITARY DYSLIPIDEMIA,CORONARY ARTERY DISEASE, INTAKE OF DRUGS LIKE LIPID MODIFYING DRUGS, ORAL CONTRACEPTIVES, METABOLIC SYNDROME.
结局指标
主要结局
1) TO ASSESS THE CLINICAL PROFILE OF PATIENTS WITH RHEUMATOID ARTHRITIS AND THEIR DISEASE ACTIVITY USING DAS 28 CRITERIA AT PRESENTATION
时间窗: 1) TO ASSESS THE CLINICAL PROFILE OF PATIENTS WITH RHEUMATOID ARTHRITIS AND THEIR DISEASE ACTIVITY USING DAS 28 CRITERIA AT BASELINE | 2) TO ASSESS THE LIPID PROFILE ABNORMALITIES IN PATIENTS DIAGNOSED WITH RHEUMATOID ARTHRITIS AT BASELINE | 3) TO DETERMINE THE CORRELATION BETWEEN LIPID PROFILE PARAMETERS AND DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS AT BASELINE
2) TO ASSESS THE LIPID PROFILE ABNORMALITIES IN PATIENTS DIAGNOSED WITH RHEUMATOID ARTHRITIS AT PRESENTATION
时间窗: 1) TO ASSESS THE CLINICAL PROFILE OF PATIENTS WITH RHEUMATOID ARTHRITIS AND THEIR DISEASE ACTIVITY USING DAS 28 CRITERIA AT BASELINE | 2) TO ASSESS THE LIPID PROFILE ABNORMALITIES IN PATIENTS DIAGNOSED WITH RHEUMATOID ARTHRITIS AT BASELINE | 3) TO DETERMINE THE CORRELATION BETWEEN LIPID PROFILE PARAMETERS AND DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS AT BASELINE
3) TO DETERMINE THE CORRELATION BETWEEN LIPID PROFILE PARAMETERS AND DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS
时间窗: 1) TO ASSESS THE CLINICAL PROFILE OF PATIENTS WITH RHEUMATOID ARTHRITIS AND THEIR DISEASE ACTIVITY USING DAS 28 CRITERIA AT BASELINE | 2) TO ASSESS THE LIPID PROFILE ABNORMALITIES IN PATIENTS DIAGNOSED WITH RHEUMATOID ARTHRITIS AT BASELINE | 3) TO DETERMINE THE CORRELATION BETWEEN LIPID PROFILE PARAMETERS AND DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS AT BASELINE
次要结局
未报告次要终点
研究者
ARINDOM KAUSHIK BORA
GAUHATI MEDICAL COLLEGE AND HOSPITAL, GUWAHATI