Reorganisation of the sensorimotor cortex following early unilateral brain damage - Cortical reorganisation following early brain injury

niversitair Medisch Centrum Utrecht0 个研究点目标入组 50 人开始时间: 待定最近更新: 2024年5月6日

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•A) preterm infants with a gestational age < 37 weeks admitted to the level III neonatal intensive care unit of the Wilhelmina Children*s Hospital, UMC Utrecht, between 1990 and 2000 with (1) a unilateral PH which subsequently did or did not result in hemiplegic cerebral palsy, and (2) an MRI during the neonatal period and often also at 24 months of age. Group (B): term infants >=37 weeks gestation admitted to our level III neonatal intensive care unit with 1) neonatal encephalopathy and/or seizures and diagnosed to have PAIS which subsequently did or did not result in hemiplegic cerebral palsy, and (2) an MRI during the neonatal period and often also at 24 months of age. Starting from the first of january 2011 we will also include children with CP due to a PAIS who were referred to the VU medical centre in Amsterdam. They will be studied in the UMCU. Furthermore we will continue including children who fulfill the inclusion criteria as mentioned earlier, but also included children at the age of six years and older.
•In 2015, an additional five patients will be included. These patients were previously too young to be included, but have now reached the age of six years or older.

•Preterm infants with lesions affecting both hemispheres, like periventricular leukomalacia. Fullterm infants with lesions affecting both hemispheres, such as injury to the central grey nuclei or watershed injury, occurring in infants with hypoxic-ischemic encephalopathy
•Infants with congenital anomalies, chromosomal disorders, or infections of the central nervous system are also not eligible for the study.

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niversitair Medisch Centrum Utrecht