New Approach for Ovarian PRP Injection for Poor Responders ; Aiming At the Highest Response Rate
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- PRP effect on ovary for better fertility outcome
研究概览
简要总结
New Approach For Ovarian PRP Injection for poor responders
详细描述
Poor ovarian responders are at high risk of unsuccessful IVF/ICSI trials. In the last few years, many studies showed significant improvement of ovarian reserve parameters after PRP injection. There was no consensus regarding the route of injection, the volume injected, the location of PRP injection inside the ovary, the number of injection and the number of the cycle in which PRP is injected.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •AMH : < 0.5 ng/ml
- •FSH: > 10 miu but < 25 miu.
- •AFC : < 5 in both ovaries
- •Poor ovarian response, in a previous IVF/ICSI trial , resulting in 3 or fewer oocytes.
- •Normal uterine cavity , demonstrated by a recent hysteroscopy
排除标准
- •Primary ovarian insufficiency with FSH > 25 miu.
- •Previous ovarian surgery or Chemotherapy.
- •On going Anticoagulant use.
- •Carcinomas or a history of chronic pelvic pain.
- •Present infection.
- •Hemoglobin level lower than 11 g/L
- •platelet count lower than 150 x 10³/μL.
结局指标
主要结局
PRP effect on ovary for better fertility outcome
时间窗: one year
This is a prospective cohort clinical observational study. Aiming at evaluating the clinical effects of injecting PRP(Platelet Rich Plasma) into ovaries, of poor responders, taking all measures which may improve the response rate. That is why we will inject PRP for 2 consecutive cycles, the first cycle via laparoscopy and the next cycle, via ultrasonography.
次要结局
未报告次要终点
研究者
Bassem Ayman Mahmoud Assaf
Medical Doctor
Benha University