NL-OMON55394已完成不适用
Sleep as a window to target traumatic memories - Sleep and traumatic memories
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 92
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •PTSD patients
- •* PTSD diagnosis according to DSM-5 criteria as assessed with the CAPS-5
- •* PTSD as primary diagnosis
- •* 18-65 years of age
- •* Capability to provide informed consentTrauma controls
- •* Having experienced a type A-trauma according to DSM-5 criteria as assessed
- •with the LEC-5 (as part of the CAPS-5).
- •* No PTSD diagnosis according to DSM-5 criteria as assessed with the CAPS-5
- •* 18-65 years of age
排除标准
- •PTSD patients
- •* Current bipolar disorder, psychotic disorder, alcohol or substance dependence
- •as assessed with the M.I.N.I. International Neuropsychiatric Interview. Note
- •comorbid depressive or anxiety disorders will be allowed if PTSD is the primary
- •* Current personality disorder as assessed with the SCID-5-P (preceded by a
- •* Active suicidal ideation
- •* Major head trauma or neurological disease, current or in history
- •* MRI contraindications such as metal implants, claustrophobia, pregnancy
- •* Self-reported inability or unease to cease smoking for 24 hours prior to
- •testing (for salivary cortisol sampling)
- •* Endocrinological disorders or regular use of corticosteroids (for salivary
- •cortisol sampling)
- •* Use psychotropic medication up to 6 weeks pre-study (or in case of
- •benzodiazepines or other sleep medication 1 week)
- •* Use of recreational drugs over the entire study period (Day -7 to Day 11).
- •* Use of alcohol during Day -7, Day 1, Night 1, Day 2, Night 2, Day 3 and Day
- •* Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline
- •* A sleep window outside 10 pm and 10 am
- •Trauma controls
- •* Any current psychiatric disorder as assessed with the M.I.N.I. International
- •Neuropsychiatric Interview or known to the patient her/himself.
- •* Lifetime PTSD diagnosis
- •* Impossibility to isolate a circumscribed traumatic memory that can be used
- •for the audioscript and for target selection in EMDR.
- •* Reactivation of the traumatic memory that is used for the audioscript and for
- •target selection in EMDR, leads to severe dissociative complaints/signs*
- •* Not speaking/understanding Dutch sufficiently
- •* Active suicidal ideation
- •* Major head trauma with co-occurring loss of consciousness in the recent past
- •* (Neurological) disorder of the central nervous system, current or in history
- •* MRI contraindications such as metal implants, claustrophobia, pregnancy
- •* Use of psychotropic medication (other than benzodiazepines or other sleep
- •medication), except when on a stable dose for at least 6 weeks (after start or
- •alteration of dosage). Use of benzodiazepines or other sleep medication in the
- •period of 1 week prior to study until end of study (Day 10).
- •* Use of recreational drugs over the entire study period (Day -7 to Day 10).
- •* Use of alcohol during Day -7, Day 1, Night 1, Day 2, Night 2, Day 3 and Day
- •* Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline
- •* A sleep window outside 10 pm and 10 am
- •* Sleep walking or REM sleep behaviour disorder
研究者
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