Clinical trial on the virucidal activity of different oral antiseptics against respiratory viruses.
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 入组人数
- 810
- 试验地点
- 1
- 主要终点
- Viral load in the salivary samples collected from each of the patients at the different times of application of the mouthwashes.
研究概览
简要总结
In patients diagnosed with COVID19, influenza A or RSV, analyze the immediate viricidal activity in saliva against these three respiratory viruses from a single rinse of different oral antiseptics, as well as the duration of this effect up to 7 hours after application.
入排标准
- 年龄范围
- 0 years 至 65+ years（0-17 Years, 65+ Years, 18-64 Years）
- 接受健康志愿者
- 是
入选标准
- •Present a diagnosis of infection by these respiratory viruses.
- •Less than 5 days have passed since the appearance of the clinical symptoms typical of each viral infection.
- •Not receiving any type of antiviral treatment.
- •Be over 16 years old.
排除标准
- •Present a history of allergy to the antiseptics evaluated.
- •Simultaneous therapy with lithium, presence of hyperthyroidism, goiter, thyroid nodules, or other acute and non-acute thyroid diseases, before or after radioactive iodine scintigraphy or treatment of thyroid carcinoma with radioactive iodine, practice of tests with tolvidin or guaiacol, to determine hemoglobin or glucose in feces or urine.
结局指标
主要结局
Viral load in the salivary samples collected from each of the patients at the different times of application of the mouthwashes.
Viral load in the salivary samples collected from each of the patients at the different times of application of the mouthwashes.
D/T ratio (where D is the amount of nucleoprotein with the PBS solution and T is the amount of nucleoprotein with the lytic solution), which represents the reciprocal relationship between the enveloped nucleoprotein and the total nucleoprotein (I/T) and corresponds to I/T = 1 -D/T. In this case, the I/T ratio serves to quantify the proportion of intact viral particles.
D/T ratio (where D is the amount of nucleoprotein with the PBS solution and T is the amount of nucleoprotein with the lytic solution), which represents the reciprocal relationship between the enveloped nucleoprotein and the total nucleoprotein (I/T) and corresponds to I/T = 1 -D/T. In this case, the I/T ratio serves to quantify the proportion of intact viral particles.
次要结局
未报告次要终点
研究者
Inma Tomás Carmona
Scientific
Fundacion Instituto De Investigacion Sanitaria De Santiago De Compostela