THE EFFICACY OF PREOPERATIVE USAGE OF GONADOTROPINE-RELEASING HORMONE AGONIST IN PATIENTS UNDERGOING TOTAL LAPAROSCOPIC HYSTERECTOMY DUE TO UTERIN FIBROIDS
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- AMOUNT OF BLEEDİNG
研究概览
简要总结
Uterin fibroids are the most common operation indication for hysterectomy. Dyring laparoscopic hysterectomy the amount of bleeding is a great difficulty.There are a lot of clinical researchs to reduce the haemorrhage during open hysterectomy but not laparoscopic procedure. In ALKU ERH clinic, researchers decided to smaller the size of fibroid by using GnRH analogues before total laparoscopic hysterectomy to reduce the haemorrhage amount.
详细描述
After randomising patients to two groups, one of the group will be controle group and the other group will be working group and researchers decided to use 3,75 mg leuprolide acetate as GnRHa subcutanously in every four week, throughout 3 months before surgery to the working group, researchers will record intraoperative amount of bleeding by measuring the blood in suction scale, the duration of surgery, difference between preoperative haemoglobin levels and uterin weight. researchers will comparise all theese parameters ibn to two groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 30 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •MYOMA UTERI
- •APPROPİATE FOR LAPAROSCOPY
排除标准
- •MALİGNANCY
研究组 & 干预措施
GnRHa
3,75 MG LEUPROLIDE ACETATE FOR EVERY 4 WEEKS THROUGHOUT 3 MONTHS BEFORE SURGERY
干预措施: PREOPERATİVE GnRHa THERAPY (LEUPROLIDE ACETATE) BEFORE SURGERY FOR UTERİN FIBROIDS (Drug)
no GnRHa
NO TREATMENT
干预措施: NO GnRHa (Drug)
结局指标
主要结局
AMOUNT OF BLEEDİNG
时间窗: 0 minute - 180 minute
WHOLE AMOUNT OF BLEEDING DURING SURGERY
DURATION AF SURGERY
时间窗: 0 MINUTE- 180 MINUTE
TIME BETWEEN INITIAL AND END OF SURGERY
次要结局
未报告次要终点
研究者
MERAL TUĞBA ÇİMŞİR
ASSOCIATE PROFESSOR
Alkü Alanya Education and Research Hospital