NL-OMON44907已完成2 期
A comprehensive and targeted therapy approach in pediatric malignant pontine gliomas - DIPG study VUmc 01
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 9
研究概览
简要总结
Trial ended prematurely
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 2 至 17（—）
入选标准
- •Patients with newly diagnosed, unresectable grade II-IV pontine glioma.
- •- Age between 3 and 18 years
- •- Willingness to perform a pregnancy test in females of child bearing age
- •- Written informed consent
- •- Platelet count * 100 x10 9/L (transfusion independent)
- •- Peripheral absolute neutrophil count (ANC) * 1.0 x10 9/L
- •- Direct bilirubin * 1.5 x upper limit of normal (ULN) for age
- •- SGPT (ALAT) < 5 x upper limit of normal (ULN) for age.
- •- Adequate Renal Function Defined As:
- •- Serum creatinine * 1.5 x upper limit of normal (ULN) for age;Phase B: patients with progressive disease after radiotherapy
排除标准
- •- Pilocytic (grade 1) astrocytomas
- •- Cervicomedullary junction tumors
- •- Presence of diffuse leptomeningeal disease.
- •- Performance status (Lansky or Karnofsky score) of 40% or less
- •- Life expectancy of less than six weeks without further therapy
- •- Pregnant or breastfeeding
- •- Other contra-indications for chemotherapy
- •- Neurofibromatosis type I
研究者
相似试验
已完成
不适用
A prospective, multicenter clinical study to evaluate the safety profile of the FlexiSurge Adhesion Barrier for the prevention of intra-abdominal adhesion formation after laparotomyvorming van adhesies na buikchirurgieadhesion formationpostoperative adhesionsNL-OMON40303Medisse BV5
已完成
3 期
Phase 3, Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial of Infigratinib for the Adjuvant Treatment of Subjects with Invasive Urothelial Carcinoma with Susceptible FGFR3 Genetic Alterations (PROOF 302)Invasive Urothelial Carcinoma with Susceptible FGFR3 Genetic AlterationsUrothelial Carcinoma10046447bladder cancerNL-OMON55032QED Therapeutics, Inc.5
已完成
3 期
Phase III, pivotal, multicentre, randomised, double-blind controlled Study to evaluate the Efficacy and Safety of Autologous Osteoblastic Cells (PREOB®) Implantation in Early Stage Non Traumatic Osteonecrosis of the Femoral Head.NL-OMON45063Bone Therapeutics6
已完成
不适用
Effects of a physical therapy protocol for patients treated for acetabular fracturesNL-OMON52235Radboud Universitair Medisch Centrum8
招募中
不适用
Combination therapy for children with malignant pontine gliomas.NL-OMON28201VU University Medical Center16