Mediterranean vs. Low-Carbohydrate Diet : Which is the Best Dietary Approach for Treating Postprandial Lipid Abnormalities and Improving Glucose Control in Type 2 Diabetic Patients?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 试验地点
- 2
- 主要终点
- Postprandial response triglyceride of chylomicrons and large VLDL
研究概览
简要总结
The aim of this intervention study was to evaluate in type 2 diabetic patients the effects on postprandial lipemia and other metabolic parameters (in both everyday life conditions and after a standard test meal) of two diets, one moderately rich in CHO, rich in fibre and with a low glycemic index (Mediterranean diet), and the other low in CHO and rich in MUFA (Low-CHO diet).Since adipose tissue, mainly through its lipolytic activities, is considered as having a pivotal role in the regulation of postprandial lipid metabolism, a further aim of our study was to clarify the role of adipose tissue in modulating the postprandial lipid response induced by the two dietary approaches by evaluating the activities of lipoprotein lipase (LPL) and hormone-sensitive lipase (HSL).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 40 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 2 diabetes
- •Stable metabolic control (HbA1c<8.0%) on diet or diet alone or diet+metformin
- •BMI<30 kg/m2 and body weight stable during the last six months.
- •Both sexes; only post-menopausal women.
- •Normal fasting lipid levels
- •No use of hypolipidemic drugs
排除标准
- •Patient with renal (serum creatinine >1.5 mg/dl) or hepatic (serum transaminases >three times upper normal values) impairment.
- •Patients with history of cardiovascular disease.
- •Pre-menopausal women.
- •Any other acute or chronic degenerative disease.
- •Anemia (Hb<12 g/dl).
- •Uncontrolled blood pressure.
- •Use of any drugs able to interfere with the study medications
结局指标
主要结局
Postprandial response triglyceride of chylomicrons and large VLDL
时间窗: 4 weeks
次要结局
- Blood glucose and insulin response to test meal(4 weeks)
- Lipolytic activities(4 weeks)