Improved Basophil Activation Test (BAT) in the Diagnostics of IgE-mediated Drug Allergy
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Sensitivity of the improved Basophil Activation Test (BAT) in the Diagnostics of Drug Allergy
研究概览
简要总结
Current study evaluates the use of the improved Basophil Activation Test (BAT) in the diagnostics of IgE-mediated allergy to antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs).
详细描述
Current study evaluates the use of the improved Basophil Activation Test (BAT) in the diagnostics of IgE-mediated allergy to antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs). Among commonly used CD63/CD203c markers, newly proposed molecules, such as CD69, CD107a, CD164, CD13, CD11b and CD300a will be assayed. Results obtained together with the other clinical data will be used to calculate sensitivity and specificity of the method.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •suspected allergy to antibiotics or NSAIDs in the last 1 year.
排除标准
- •autoimmune diseases;
- •hepatitis B/C;
- •other acute or chronic infectious diseases;
- •malignant neoplasms;
- •leukemia;
- •other severe acute or chronic intercurrent diseases;
- •pregnancy/lactation;
- •refuse of patient to participate in the trial.
结局指标
主要结局
Sensitivity of the improved Basophil Activation Test (BAT) in the Diagnostics of Drug Allergy
时间窗: 1 month
Sensitivity of the improved Basophil Activation Test (BAT) in the diagnostics of allergy to antibiotics or NSAIDs
Specificity of the improved Basophil Activation Test (BAT) in the Diagnostics of Drug Allergy
时间窗: 1 month
Specificity of the improved Basophil Activation Test (BAT) in the diagnostics of allergy to antibiotics or NSAIDs
次要结局
未报告次要终点
研究者
Andrei Y. Hancharou
Head of the Laboratory for Immunology and Cellular Biotechnology
The Republican Research and Practical Center for Epidemiology and Microbiology