Effect of End-range Mobilization in Addition to Conservative Therapy on Decrease of Pressure Pain Threshold
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- change of peripheral sensitivity
研究概览
简要总结
The effect of mobilizations on decrease of peripheral and central sensitivity has been proven in KOA. Furthermore, the effect of conservative therapy has also been proven in the increase of pain threshold in KOA. However, no study has investigated the effect of these interventions combined till date in KOA.
The aim of the present study is to investigate the short-term and long-term effect of end-range mobilization in addition to conservative therapy on decrease of pressure pain threshold in KOA.
详细描述
The positive effect of different manual mobilizations have been proven in the management of knee osteoarthritis (KOA). Pressure pain threshold, as a measure of somatosensory function, is a well-applied measurement technique for the pain perception in KOA. The effect of mobilizations on decrease of peripheral and central sensitivity has been proven in KOA. Furthermore, few studies has revealed the effect of conservative therapy as an effective intervention in the increase of pain threshold. However, no study has investigated the effect of these interventions combined till date in KOA, which could give a long-lasting effect in the decrease of sensitization in KOA.
Therefore, the aim of the present study is to investigate the short-term and long-term effect of end-range mobilization in addition to conservative therapy on decrease of pressure pain threshold in KOA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •clinical classification criteria of knee osteoarthritis according to the American College of Rheumatology
- •categorization as End of Range Problem based on Maitland manual therapy
- •unilateral/bilateral moderate-to-severe symptomatic tibiofemoral KOA with radiographic evidence of Kellgren-Lawrence scale 2 or 3
- •pain during weight-bearing activities at least within 6 months
- •at least 90° knee flexion
- •sufficient mental status
排除标准
- •acute inflammation of the knee
- •total knee replacement in the opposite side
- •class II. obesity (body mass index>35kg/m2)
- •severe degenerative lumbar spine disease (e.g. spondylolisthesis)
- •systemic inflammatory arthritic or neurological condition
- •physiotherapy/balneotherapy attendance or manual therapy within 3 months
- •intraarticular injections in the prior 12 months
- •use of walking aid
- •contraindication for manual therapy
- •complex regional pain syndrome
- •cognitive impairment
结局指标
主要结局
change of peripheral sensitivity
时间窗: following 3-month
peripheral sensitivity (pressure pain threshold) assessed at the local knee
次要结局
- change of central sensitivity(following 3-month)
- change of Timed Up and Go test(following 3-month)
- change of pain intensity during physical performance(following 3-week rehabilitation)
- change of pain during physical performance(following 3-month)
- degree of knee flexion during passive movement at the onset of knee pain(following 3-month)
- change of general pain intensity(following 3-month)
- strength of resistance of passive knee flexion at the onset of knee pain(following 3-month)