Effect of Time of Exercise Re-training on Functional Capacity in Individuals With Chronic Obstructive Pulmonary Disease (COPD)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 90
- 试验地点
- 2
- 主要终点
- 6-minute walk test (6MWT)
研究概览
简要总结
Pulmonary rehabilitation (PR) is an effective intervention for reducing hospital readmissions, secondary events, and mortality in patients with respiratory pathologies.
The program should not be improved by introducing new subjects such as circadian rhythm.
详细描述
Respiratory diseases are a leading cause of death in developed countries. To avoid complications and recurrences, secondary prevention in patients with respiratory diseases is essential. Pulmonary rehabilitation (PR) is a well-established and effective treatment that is supervised by medical professionals and conducted in dedicated centres. It has been shown to reduce hospital readmissions, secondary events, and patient mortality.
The timing of reconditioning is crucial. Previous studies have indicated that training times affect strength and power gains. Additionally, the time of day for training can significantly impact progress in aerobic capacity.
Disturbances to the biological clock can have consequences for people with respiratory pathologies, particularly an alteration in muscular function.
Therefore, studying the temporal specificity of exercise re-training in patients with respiratory diseases is of interest.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Patient with chronic obstructive pulmonary disease (COPD)
- •Registered for respiratory re-education and rehabilitation at the Clinique de la Mitterie
- •Number of rehabilitation sessions at least 18 over 4 weeks
- •Written informed consent signed by the patient
- •Membership of a social security
排除标准
- •- cardiovascular contraindications to exercise
- •unstable respiratory status (uncompensated respiratory acidosis)
- •conditions interfering with the pulmonary rehabilitation process (progressive neuromuscular disease, psychiatric illness)
研究组 & 干预措施
Morning group
Endurance and muscular exercise can be performed in the morning, either at 9:00am or 9:45am, or vice versa.
干预措施: Pulmonary rehabilitation (Other)
Afternoon group
Endurance and muscular exercise can be performed in the afternoon, from 3:00 pm to 3:45 pm, or vice versa.
干预措施: Pulmonary rehabilitation (Other)
结局指标
主要结局
6-minute walk test (6MWT)
时间窗: 15 minutes
Walking distance in a test
次要结局
- Time limit test (Time-lim)(0 to 900 secondes)
- Sit to stand test (STT)(1 minute)
- Single arm curl Test (SAC)(1 minute)
- Pittsburgh Sleep Quality Index(10 minutes. The total score ranges from 0 to 21, with 0 indicating no difficulties and 21 indicating major difficulties.)
- Single-leg stance test (SLT)(1 minute)
- Hospital Anxiety and Depression Scale (HAD)(10 minutes. The maximum mark for each score is 21 and the minimum mark is 0. The higher the score, the more depressed or anxious the person.)
研究者
Michaël RACODON
Head of clinical research
Clinique de la Mitterie