Characteristics and Outcomes of Patients With Pregnancy Related Acute Kidney Injury in Assiut University Hospitals: a Single-center Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 57
- 主要终点
- The occurance of renal recovery
研究概览
简要总结
The primary objective of this study is to identify characteristics of patient with PR AKI treated in Assiut university hospital
Secondary outcomes:
- Assessment of pregnancy related AKI maternal outcome (complete recovery , partial recovery or progress to ESRD) within 3 months duration
- To identify predictors of unfavorable outcome of patient with pregnancy related AKI
详细描述
Acute kidney Injury (AKI) is a syndrome which is characterized by an rapid deterioration of the kidney function , manifested by increase in serum creatinine level with or without reduced urine output and linked to high rate of morbidity and mortality .AKI is considered a major public health problem despite much improvmnent in heakth care and especially, most of them (about 85 %) in developing countries with low resources.Pregnancy related AKI ( PR -AKI ) is a major obstetric complication which may cause termination of pregnancy (TOP ), Intensive care unit ( ICU ) admission , need for dialysiy , both maternal and perinatal morbidity and mortality with maternal mortality rang from 9% to 55 % .
PR-AKI has a major risk factors include preeclampsia which is the most common cause (15-20%) , hyperemesis gravidarum , acute fatty liver of pregnancy and placental abruption , puerperal sepsis and septic abortion .The maternal outcome of pregnancy related AKI include complete recovery with return of serum creatinine to normal (> 1.4 mg /dl ) about (40-75% ), partial recovery(4-9% require dialysis about 4 months after delivery) , progress to End stage renal disease (1.5 - 2.5 %) or maternal mortality . The maternal mortality rate (MMR) increases with increasing severity of pregnancy-related complications and can range from 13 to 24% in developing countries due to PR-AKI .
Timely identification of patients and management of underlying conditions is considered the cornerstone to improve maternal outcome.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women (>18 years) who developed AKI with or without need for dialysis treatment during pregnancy, childbirth , post abortion period and /or puerperium
- •AKI as defined by KDIGO definition as follows:
- •Increase in serum creatinine > 0.3 mg/dl within 48
- •Increase in serum creatinine > 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days.
- •urine volume of < .5 ml / kg / hours
排除标准
- •Patients with preexisting kidney disease before pregnancy
- •Patients with AKI not related to pregnancy.
- •Patients with uncertain history for incident time of AKI.
- •Patients refuse to participate in the study
结局指标
主要结局
The occurance of renal recovery
时间窗: After the insult and up to the subsequent 3 month duration
The occurance of renal recovery measured by serum creatinine , eGFR , urinary proteins and need for dialysis after the insult and up to the subsequent 3 month duration
次要结局
未报告次要终点
研究者
Mahmoud Saber Mohamed Ali
MBBCH , principal investigator
Assiut University