Neutrophile Gelatinase Associated Lipocalin Evaluation in Septic Acute Kidney Injury
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 1
研究概览
简要总结
Acute kidney injury (AKI) is a major organ failure in septic shock. Current medical tests (serum creatinine and urea) cannot identify AKI until approximately 48 hours after it occurs. Neutrophil gelatinase-associated lipocalin (NGAL) may be able to predict ischemic AKI more effectively and faster than serum creatinine and urea levels.
The purpose of this study is to take a blood sample from patients at admission and then at 24 and 48 hours after to test their plasma for NGAL and compare the NGAL levels to their creatinine and urea levels. The investigators hypothesize that NGAL is an earlier marker to classify the kidney failure as acute tubular necrosis or pre-renal azotemia than creatinine and urea.
详细描述
Primary Outcome Measures:
To correlate elevated serum NGAL with the diagnosis of intrinsic acute kidney injury in septic shock
Secondary Outcome Measures :
To compare serum NGAL with serum creatinine, serum urea and urine output in septic AKI Death within the intensive care unit Death from all causes at 28 days after inclusion
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients showing signs of infection and hypotension requiring the use of epinephrine despite of an appropriate fluid challenge.
- •18 years of age or older
排除标准
- •Age under 18 years
- •Prisoners or other institutionalized or vulnerable individuals
- •Participation in an interventional clinical study within the previous 30 days