Topical Insulin in Treatment of Neurotrophic Corneal Ulcer,Efficacy And Safety
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 14
- 主要终点
- Decrease in ulcer size and the increase in visual acuity .
研究概览
简要总结
To evaluate Safety and efficacy of topical insulin in treatment of neurotrophic corneal ulcers
详细描述
Neurotrophic keratopathy is a degenerative disease of the corneal epithelium resulting from impaired corneal innervation. A reduction In corneal sensitivity or complete corneal anesthesia is the hallmark of this disease and is responsible for producing epithelial keratopathy, ulceration and perforation.
Because decreased corneal sensitivity is the hallmark sign of neurotrophic keratitis (NK), corneal sensitivity testing should be performed as soon as It is suspected
There are 2 common ways to test-one qualitative, the other quantitative:
The qualitative method is most commonly used In clinic and often achieved with a cotton tipped applicator because It is easily accessible.
The most common quantitative method is the handheld esthesiometer (Cochet-Bonnet).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with neurotrophic corneal ulcers caused by:
- •Herpes simplex or Herpes zoster viral infection
- •Topical anesthetics abuse
- •Chemical and physical burn
- •Chronic CL wear
- •Following LASIK,PRK,CXL
- •Following vitrectomy and endophotocoagulation for retinal detachment
- •Diabetes mellitus
- •Trigeminal neuralgia surgery
排除标准
- •Non compliant patients with the study protocol
研究组 & 干预措施
insulin eye drop
干预措施: insulin eye drops (Drug)
结局指标
主要结局
Decrease in ulcer size and the increase in visual acuity .
时间窗: baseline
To evaluate the effect of topical insulin eye drops in treatment of neurotrophic corneal ulcer.
次要结局
未报告次要终点
研究者
Gehad Abd Elrahim Ahmed
Doctor
Assiut University