NCT04939753已完成不适用
Incidence of Nephrogenic Diabetes Insipidus During Prolonged Sevoflurane Sedation in the Intensive Care Unit: a Retrospective Analysis
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Nephrogenic Diabetes Insipidus prevalence
研究概览
简要总结
The investigators aim to retrospectively explore the electronic medical records of all patients who were admitted to the Intensive Care Unit (ICU) of the UZ Brussels in the last 10 years (March 1st 2011- March 1st 2021) and who received prolonged sedation (>24h) with sevoflurane.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Sevoflurane administration >24h
- •18 years and older
排除标准
- •< 18 years old
- •Pre-existing diabetes insipidus
- •Use of drugs at risk for diabetes insipidus (including lithium, cisplatin)
- •Hypercalcemia (persistently >2.75 mmol/L)
- •Pituitary or acute brain surgery
- •Patients requiring continuous renal replacement therapy
- •Pregnancy
研究组 & 干预措施
Sevoflurane group
Patients that received sevoflurane while in ICU care.
干预措施: Sevoflurane (Drug)
结局指标
主要结局
Nephrogenic Diabetes Insipidus prevalence
时间窗: up to 8 weeks
How many patients under sevoflurane sedation ultimately develop NDI? NDI confirmed by demonstrating the absence of a urine concentrating response to exogenous Arginine Vasopressine.
次要结局
- Number of patients with electrolyte abnormalities as assessed by lab results.(during hospitalization, up to 8 weeks.)
- Number of patients with excessive urine output(during hospitalization, up to 8 weeks.)
- Number of patients with an abnormal physical examination.(during hospitalization, up to 8 weeks.)
- Number of patients with urine with an abnormal osmolality(during hospitalization, up to 8 weeks.)
- Number of patients that show an abnormal amount of fluid intake(during hospitalization, up to 8 weeks.)
- Number of patients that have an abnormal abdominal echo of the bladder.(during hospitalization, up to 8 weeks.)
- Number of symptoms of NDI(up to 8 weeks)
- Timing of symptoms of NDI(up to 8 weeks)
- Number of patients that develop risk factors of NDI(up to 8 weeks)
- Amount of time patient was placed under sevoflurane sedation.(up to 8 weeks)
研究者
研究点 (1)
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