The feasibility of 18F-FMISO imaging for atherosclerotic and non-atherosclerotic intra-arterial hypoxia in the setting of peripheral arterial disease requiring amputation.

Royal Perth Hospital0 个研究点目标入组 12 人开始时间: 2022年3月21日最近更新: 2023年9月12日

适应症

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•Male or post-menopausal female (defined as the absence of menses of >12 months in the absence of pathology) above the age 40 who have undergone a clinical decision to proceed to below knee or above knee amputation
•-A lower limb computed-tomography angiography performed in the last 18 months and performed exclusively for clinical purposes
•-Have some evidence of arterial disease on lower limb computed-tomography angiography

•-Inability to provide informed consent
•-A diagnosis of chronic obstructive pulmonary disease or other respiratory disease that currently requires home oxygen therapy
•-A resting oxygen saturation (measured at time of screening and in the absence of oxygen therapy) below 92%
•-eGFR less than or equal to 30 at time of screening
•-Symptomatic heart failure impairing an ability to lie flat on for imaging purposes or requiring supplemental oxygen therapy
•-A prior below knee, above knee or higher, lower limb amputation of the other limb
•-Acute lower limb ischemia requiring urgent revascularisation or emergent amputation
•-Prior orthopaedic surgery of the lower limb with foreign material remaining in-situ
•-In-patients requiring nurse escort for inter-hospital transport
•-Recent or current lung cancer or cancer of the lower limb (excluding Non-melanoma skin cancer)
•-Known cardiac arrhythmia that precludes ECG gating

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